Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Abstract Text:

Li Cong,Jessica Gasser,Jessica Zhao,Baofeng Yang,Fanghong Li,Allan Z Zhao,Li Cong,Jessica Gasser,Jessica Zhao,Baofeng Yang,Fanghong Li,Allan Z Zhao,Li Cong,Jessica Gasser,Jessica Zhao,Baofeng Yang,Fanghong Li,Allan Z Zhao,

Obesity is one of the well-established risk factors for endometrial cancer. Recent clinical studies have demonstrated that circulating adiponectin concentrations are inversely correlated with the incidence of endometrial carcinoma. Such epidemiological findings are consistent with the paradoxical observations that adiponectin levels are reduced in obesity. This study investigated the direct effects of adiponectin on two endometrial carcinoma cell lines, HEC-1-A and RL95-2. These cell lines express both variants of adiponectin receptors, adipo-R1 and adipo-R2. Adiponectin treatment leads to suppression of cell proliferation in both cell types, which is primarily due to the significant increase of cell populations at G(1)/G(0)-phase and to the induction of apoptosis. The inhibition of growth in these two cell lines appears to be mediated by different signaling pathways. Although adiponectin treatment markedly increases the phosphorylation (Thr172) of AMP-activated protein kinase alpha in both HEC-1-A and RL95-2 within 30 min, prolonged exposure (48 h) leads to inactivation of Akt as well as reduction of cyclin D1 protein expression in HEC-1-A cells. In contrast, similar treatment of RL95-2 cells with adiponectin, while having no effects on Akt activity and cyclin D1 expression, causes a decrease in cyclin E2 expression and the activity of mitogen-activated kinase (p42/44). We conclude that adiponectin exerts direct anti-proliferative effects on HEC-1-A and RL95-2 cells by inducing cell cycle arrest and apoptosis. Depending on the genotypes of the endometrial cancer cells, the inhibitory effects of adiponectin are associated with the reduction of different pro-growth regulators of cell cycle and signaling proteins. Our study thus provides a cellular mechanism underlying the linkages between endometrial cancer and obesity.

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Publishing Authors By Initials

L Cong,J Gasser,J Zhao,B Yang,F Li,AZ Zhao,L Cong,J Gasser,J Zhao,B Yang,F Li,AZ Zhao,L Cong,J Gasser,J Zhao,B Yang,F Li,AZ Zhao,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrine-related cancer

VOLUME: 14

Page Numbers: 713-20

Journal Abbreviation: Endocr. Relat. Cancer

ISSN: 1351-0088

DAY: 4

MONTH: Sep

YEAR: 2007

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9436481

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.

AFFILIATION: Department of Cell Biology and Physiology, University of Pittsburgh, S-326, BSTWR, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA.

Country: England

AGENCY: United States NIDDK

GRANT: 5P30 DK046204

ACRONYM: DK

MEDLINETA: Endocr Relat Cancer

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2 Related Publications

• Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse.
• Effect of vitamin E succinate on expression of TGF-beta1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells.
• Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
• Vascular osteomuscular autograft prefabrication using coral, type I collagen and recombinant human bone morphogenetic protein-2.
• [Acute physiology and chronic health evaluation II system to prevent and treat infection in surgical ICU]
• [An experimental study on the effect of xenogeneic bone combined with human recombinant bone morphogenetic protein-2]
• [Anterior instrumentation for the treatment of tuberculotic spinal deformity]
• [Arthrowand technique under arthroscope in diagnosis and treatment of knee disease]
• [Breast ptosis correction with a knitted polypropylene mesh]
• [Changes in autoantibody against cardiovascular AT1-receptor during development of renovascular hypertension in rats]
• [Characters of uncoupling protein and its relation with obesity]
• [Classification and treatment of asymmetrical breast deformity]
• [Clinical analysis of 44 cases of recurrent thyroid carcinoma]
• [Clinico-pathologic and prognostic studies on lung adenocarcinoma patients under 40 years of age]
• [Comparative study of human fetal and adult bone marrow derived mesenchymal stem cells]
• [Different serum lipid adjustment drugs for the treatment of hyperlipidemic fatty liver]
• [Effects of air pollution from burning coal on respiratory diseases in adults]
• [Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]
• [Inhibition of human gastric carcinoma cell growth by vitamin E succinate]
• [Isolation and identification of chemical constituents from Albizia julibrissin Durazz.]
• [Peritoneal lavage cytology in 66 patients with gastric carcinoma]
• [Relationship between endotracheal intubation pattern and nosocomial infection of medical staff during treatment of severe acute respiratory syndrome]
• [Research on embryonic stem cells]
• [State of the art in the study of postburn ischemic/hypoxic injury]
• [Study of autofluorescence spectrum of dilute gastric juice in the diagnosis of gastric carcinoma]
• [Study on the chemical components of edible oil fume in kitchen and its genotoxity on Drosophila]
• [Study on vitamin E succinate inducing apoptosis of human gastric carcinoma cell]
• [Survey of taenia saginata infection in students in Harbin city]
• [The clinical staging and tissue bacterial quantification in the diagnosis of burn wound sepsis]
• [Ultrasonically guided radio-frequency ablation of liver tumors with a clustered electrode: a report of 100 cases]