Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z.

Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z. Research Abstract Details 

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Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z. Abstract Text:

Sahib S Khalsa,Steven A Moore,Gary W Van Hoesen,

Hughlings Jackson's insightful bedside observations of patients with epilepsy paved the way for the first effective surgical epilepsy treatments. Jackson's most famous case, that of Doctor Z, concerned a medical doctor with partial complex seizures who was reported to have a discrete and circumscribed medial temporal lobe (mTL) lesion on autopsy. Although integral to Jackson's argument for mTL resection, the case remains controversial due to inadequate pathological descriptions of Doctor Z's lesion. This motivated us to describe the case of a patient, whom we call Patient A, who suffered from a form of epilepsy similar to that of Doctor Z, accompanied by a discrete and circumscribed mTL lesion in the exact same location. The lesion, a cavernous hemangioma, spared the hippocampus and was restricted to the lateral aspect of the entorhinal cortex. This finding validates Jackson's original description and suggests that the entorhinal cortex can play a role in seizure genesis.

Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z. Publishing Authors By Initials

SS Khalsa,SA Moore,GW Van Hoesen,

For similar nervous system diseases: neurologic manifestations: neurobehavioral manifestations: memory disorders research abstracts see: nervous system diseases: neurologic manifestations: neurobehavioral manifestations: memory disorders research

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Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Epilepsy & behavior : E&B

VOLUME: 9

Page Numbers: 524-31

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ISSN: 1525-5050

DAY: 30

MONTH: 08

YEAR: 2006

Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z. Information

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LANGUAGE: eng

NlmUniqueID: 100892858

Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z. Keywords Mesh Terms:

KEYWORDS: Memory Disorders

MESH TERMS: pathology

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Grant and Affiliation Information for Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z.

AFFILIATION: Department of Neurology, 1216 MERF, University of Iowa, Iowa City, IA 52242, USA. sahib-khalsa@uiowa.edu <sahib-khalsa@uiowa.edu>

Country: United States

AGENCY: United States NINDS

GRANT: P0 NS 19632

ACRONYM: NS

MEDLINETA: Epilepsy Behav

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