Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Research Abstract Details 

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Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Abstract Text:

Leigh Coultas,Susanna Terzano,Tim Thomas,Anne Voss,Kate Reid,Edouard G Stanley,Clare L Scott,Philippe Bouillet,Perry Bartlett,Jonathan Ham,Jerry M Adams,Andreas Strasser,

The pro-apoptotic BH3-only members of the Bcl2 family, crucial initiators of cell death, are activated by a diverse array of developmental cues or experimentally applied stress stimuli. We have investigated, through gene targeting in mice, the biological roles for the BH3-only family member HRK (also known as DP5) in apoptosis regulation. Hrk gene expression was found to be restricted to cells and tissues of the central and peripheral nervous systems. Sensory neurons from mice lacking Hrk were less sensitive to apoptosis induced by nerve growth factor (NGF) withdrawal, consistent with the induction of Hrk following NGF deprivation. By contrast, cerebellar granule neurons that upregulate Hrk upon transfer to low-K+ medium underwent apoptosis normally under these conditions in the absence of Hrk. Furthermore, loss of Hrk was not sufficient to rescue the neuronal degeneration in lurcher mutant mice. Despite previous reports, no evidence was found for Hrk expression or induction in growth-factor-dependent haematopoietic cell lines following withdrawal of their requisite cytokine, and haematopoietic progenitors lacking HRK died normally in response to cytokine deprivation. These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells.

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Publishing Authors By Initials

L Coultas,S Terzano,T Thomas,A Voss,K Reid,EG Stanley,CL Scott,P Bouillet,P Bartlett,J Ham,JM Adams,A Strasser,

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Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 2044-52

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 29

MONTH: 05

YEAR: 2007

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Information

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LANGUAGE: eng

NlmUniqueID: 52457

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Keywords Mesh Terms:

KEYWORDS: Neuropeptides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Information

Substance Name: Nerve Growth Factor

Registry Number: 9061-61-4

Grant and Affiliation Information for Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

AFFILIATION: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

Country: England

AGENCY: United States NCI

GRANT: CA80188

ACRONYM: CA

MEDLINETA: J Cell Sci

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