How regulators of G protein signaling achieve selective regulation.

How regulators of G protein signaling achieve selective regulation. Research Abstract Details 

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How regulators of G protein signaling achieve selective regulation. Abstract Text:

Guo-Xi Xie,Pamela Pierce Palmer,

The regulators of G protein signaling (RGS) are a family of cellular proteins that play an essential regulatory role in G protein-mediated signal transduction. There are multiple RGS subfamilies consisting of over 20 different RGS proteins. They are basically the guanosine triphosphatase (GTPase)-accelerating proteins that specifically interact with G protein alpha subunits. RGS proteins display remarkable selectivity and specificity in their regulation of receptors, ion channels, and other G protein-mediated physiological events. The molecular and cellular mechanisms underlying such selectivity are complex and cooperate at many different levels. Recent research data have provided strong evidence that the spatiotemporal-specific expression of RGS proteins and their target components, as well as the specific protein-protein recognition and interaction through their characteristic structural domains and functional motifs, are determinants for RGS selectivity and specificity. Other molecular mechanisms, such as alternative splicing and scaffold proteins, also significantly contribute to RGS selectivity. To pursue a thorough understanding of the mechanisms of RGS selective regulation will be of great significance for the advancement of our knowledge of molecular and cellular signal transduction.

How regulators of G protein signaling achieve selective regulation. Publishing Authors By Initials

GX Xie,PP Palmer,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

How regulators of G protein signaling achieve selective regulation. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of molecular biology

VOLUME: 366

Page Numbers: 349-65

Journal Abbreviation: J. Mol. Biol.

ISSN: 0022-2836

DAY: 15

MONTH: 11

YEAR: 2006

How regulators of G protein signaling achieve selective regulation. Information

Number of References: 164

LANGUAGE: eng

NlmUniqueID: 2985088

How regulators of G protein signaling achieve selective regulation. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: How regulators of G protein signaling achieve selective regulation. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for How regulators of G protein signaling achieve selective regulation.

AFFILIATION: Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.

Country: England

AGENCY: United States NINDS

GRANT: R01 NS042593-03

ACRONYM: NS

MEDLINETA: J Mol Biol

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