House dust (1-3)-beta-D-glucan and wheezing in infants.

House dust (1-3)-beta-D-glucan and wheezing in infants. Research Abstract Details 

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House dust (1-3)-beta-D-glucan and wheezing in infants. Abstract Text:

Y Y Iossifova,T Reponen,D I Bernstein,L Levin,H Kalra,P Campo,M Villareal,J Lockey,G K K Hershey,G LeMasters,Y Y Iossifova,T Reponen,D I Bernstein,L Levin,H Kalra,P Campo,M Villareal,J Lockey,G K K Hershey,G LeMasters,

BACKGROUND: (1-3)-Beta-D-glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1-3)-beta-D-glucan during infancy. We examined the association between (1-3)-beta-D-glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder. METHODS: (1-3)-Beta-D-glucan and endotoxin exposures were measured in settled dust collected from infants' primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white. RESULTS: Exposure to high (1-3)-beta-D-glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95% CI = 0.16-0.93] and recurrent wheezing combined with allergen sensitization (aOR = 0.13, 95% CI = 0.03-0.61). Similar trends were found between (1-3)-beta-D-glucan concentrations and allergen sensitization (aOR = 0.57, 95% CI = 0.30-1.10). In contrast, recurrent wheezing with or without allergen sensitization was positively associated with low (1-3)-beta-D-glucan exposure within the first quartile (aOR = 3.04, 95% CI = 1.25-7.38; aOR = 4.89, 95% CI = 1.02-23.57). There were no significant associations between endotoxin exposure and the studied health outcomes. CONCLUSIONS: This is the first study to report that indoor exposure to high levels of (1-3)-beta-D-glucan (concentration >60 microg/g) is associated with decreased risk for recurrent wheezing among infants born to atopic parents. This effect was more pronounced in the subgroup of allergen-sensitized infants.

House dust (1-3)-beta-D-glucan and wheezing in infants. Publishing Authors By Initials

YY Iossifova,T Reponen,DI Bernstein,L Levin,H Kalra,P Campo,M Villareal,J Lockey,GK Hershey,G LeMasters,YY Iossifova,T Reponen,DI Bernstein,L Levin,H Kalra,P Campo,M Villareal,J Lockey,GK Hershey,G LeMasters,

For similar beta-glucans research abstracts see: beta-glucans research

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MEDLINE DATE:

House dust (1-3)-beta-D-glucan and wheezing in infants. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Allergy

VOLUME: 62

Page Numbers: 504-13

Journal Abbreviation:

ISSN: 0105-4538

DAY: 3

MONTH: May

YEAR: 2007

House dust (1-3)-beta-D-glucan and wheezing in infants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7804028

House dust (1-3)-beta-D-glucan and wheezing in infants. Keywords Mesh Terms:

KEYWORDS: beta-Glucans

MESH TERMS: immunology

Chemical & Substance for Abstract: House dust (1-3)-beta-D-glucan and wheezing in infants. Information

Substance Name: beta-Glucans

Registry Number: 0

Grant and Affiliation Information for House dust (1-3)-beta-D-glucan and wheezing in infants.

AFFILIATION: Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.

Country: Denmark

AGENCY: United States PHS

GRANT: T42/CCT510420

ACRONYM: ES

MEDLINETA: Allergy

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