Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection.

Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection. Research Abstract Details 

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Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection. Abstract Text:

J Tanaka,T Ohkusa,T Yokoyama,T Matsuhisa,T Kawai,H Hashimoto,T Tomita,K Hori,K Nakajima,T Matsumoto,H Miwa,

Aim To systematically determine the usefulness of Helicobacter pylori IgG antibody titer decline as a predictor of treatment success after H. pylori eradication in large patient samples. Patients and Methods Serum samples from 258 H. pylori positive patients (52.8 yrs, 65% males) were retrospectively collected from five medical centers, and H. pylori titers were quantitatively determined by ELISA. Serial serum samples were collected at baseline and for up to 4.9 years after treatment. 169 patients underwent successful eradication while 89 remained infected. The median total observation period was 635 days (range, 51 to 1,800 days). Chronological changes in H. pylori titers were analyzed and compared between cured and infection persistent subjects. Results The proportion of infection persistent patients who developed negative H. pylori IgG antibody titers was below 5%. A receiver operating characteristic (ROC) curve for the confirmation of successful eradication according to the percent decline over baseline at each time-point showed that a 60% decline at 1 year or more after eradication treatment strongly correlated with successful eradication (sensitivity = 90% and specificity = 87%). Conclusion A 60% decline in H. pylori IgG titers (HEL-p kit) from baseline to one year or greater is a reliable predictor of successful H. pylori eradication.

Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection. Publishing Authors By Initials

J Tanaka,T Ohkusa,T Yokoyama,T Matsuhisa,T Kawai,H Hashimoto,T Tomita,K Hori,K Nakajima,T Matsumoto,H Miwa,

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Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Alimentary pharmacology & therapeutics

VOLUME: 24 Suppl 4

Page Numbers: 239-48

Journal Abbreviation: Aliment. Pharmacol. Ther.

ISSN: 0269-2813

DAY: 9

MONTH: Dec

YEAR: 2006

Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection.

AFFILIATION: Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.

Country: England

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MEDLINETA: Aliment Pharmacol Ther

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