Host immune competence and local ischemia affects the functionality of engineered vasculature.

Host immune competence and local ischemia affects the functionality of engineered vasculature. Research Abstract Details 

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Host immune competence and local ischemia affects the functionality of engineered vasculature. Abstract Text:

Ruth R Chen,Jonathan K Snow,Jack P Palmer,Angela S Lin,Craig L Duvall,Robert E Guldberg,David J Mooney,

OBJECTIVE: Localized and sustained delivery of vascular endothelial growth factor (VEGF) is a promising approach to overcome the limited efficacy of bolus delivery. The authors examined the effects of host immune competence and local ischemia on the functionality of new vessel networks formed with this approach. METHODS: Vessel structure and perfusion resulting from implantation of porous 85:15 poly(lactide-co-glycolide) scaffolds releasing VEGF165 were measured in both subcutaneous tissue and ischemic hindlimbs of immune competent C57BL/6 and immune deficient SCID mice. RESULTS: Sustained VEGF delivery resulted in a similar approximately 100% increase in vessel density within scaffolds in both implant sites, and both animal models. However, the resulting perfusion within scaffolds implanted in subcutaneous tissue increased modestly versus control (18-35%), while perfusion increased 52-110% above control when VEGF-releasing scaffolds were placed in ischemic hindlimbs of C57BL/6 or SCID mice. VEGF delivery improved perfusion in the entire ischemic limb (55 +/- 18% of the normal value by week 6; 138% increase over control) in SCID mice. Although C57BL/6 mice demonstrated spontaneous recovery from ischemia, VEGF delivery accelerated recovery as compared to control. CONCLUSIONS: Localized and sustained VEGF delivery can create functional vasculature that amplifies recovery of tissue ischemia. However, increases in local and regional perfusion were highly dependent on the implantation site and the animal model.

Host immune competence and local ischemia affects the functionality of engineered vasculature. Publishing Authors By Initials

RR Chen,JK Snow,JP Palmer,AS Lin,CL Duvall,RE Guldberg,DJ Mooney,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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Host immune competence and local ischemia affects the functionality of engineered vasculature. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microcirculation (New York, N.Y. : 1994)

VOLUME: 14

Page Numbers: 77-88

Journal Abbreviation:

ISSN: 1073-9688

DAY: 3

MONTH: Feb

YEAR: 2007

Host immune competence and local ischemia affects the functionality of engineered vasculature. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9434935

Host immune competence and local ischemia affects the functionality of engineered vasculature. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Host immune competence and local ischemia affects the functionality of engineered vasculature. Information

Substance Name: Polyglactin 910

Registry Number: 34346-01-5

Grant and Affiliation Information for Host immune competence and local ischemia affects the functionality of engineered vasculature.

AFFILIATION: Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL069957

ACRONYM: HL

MEDLINETA: Microcirculation

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