Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression.

Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression. Research Abstract Details 

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Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression. Abstract Text:

Teruyasu Ohno,Michael Pelzer,Mikko Larsen,Patricia F Friedrich,Allen T Bishop,Teruyasu Ohno,Michael Pelzer,Mikko Larsen,Patricia F Friedrich,Allen T Bishop,

A novel method of living bone allotransplantation combining microvascular repair of the nutrient circulation, implantation of host-derived arteriovenous (AV) bundles, and short-term immunosuppression is described. We hypothesized that neoangiogenesis from the implanted vessels would maintain graft viability and circulation after withdrawal of FK506 (Tacrolimus) immunosuppression. Vascularized femoral transplantation was performed between DA and PVG rats. In addition to microsurgical pedicle anastomoses, a saphenous AV bundle from the recipient animal was implanted in the medullary space. Ninety-seven rats were randomly allocated to groups differing in immunosuppression and AV bundle patency. Implanted vessels significantly improved capillary density and bone blood flow in nonimmunosuppressed and immmunosuppressed groups, respectively. A lower incidence of spontaneous AV bundle thrombosis was found with Tacrolimus treatment. More viable osteocytes were seen at 4 weeks when the AV bundle was patent. Further investigations may confirm host-derived neoangiogenesis as an alternative to tolerance induction or immunosuppression in bone allotransplantation. (c) 2007 Wiley-Liss, Inc. Microsurgery, 2007.

Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression. Publishing Authors By Initials

T Ohno,M Pelzer,M Larsen,PF Friedrich,AT Bishop,T Ohno,M Pelzer,M Larsen,PF Friedrich,AT Bishop,

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Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Microsurgery

VOLUME: 27

Page Numbers: 657-63

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ISSN: 0738-1085

DAY: 5

MONTH: 11

YEAR: 2007

Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Host-derived angiogenesis maintains bone blood flow after withdrawal of immunosuppression.

AFFILIATION: Department of Orthopedic Surgery, Microvascular Research Laboratory, Mayo Clinic, Rochester, MN.

Country: United States

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MEDLINETA: Microsurgery

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