Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Research Abstract Details 

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Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Abstract Text:

Katsumi Shigemura,Jack L Arbiser,Shi-Yong Sun,Majd Zayzafoon,Peter A S Johnstone,Masato Fujisawa,Akinobu Gotoh,Babette Weksler,Haiyen E Zhau,Leland W K Chung,

BACKGROUND: Honokiol, a soluble nontoxic natural product derived from Magnolia spp., has been shown to induce apoptosis in malignant cells. The effect of honokiol and the combined therapy with docetaxel on prostate cancer (PCa) growth and bone metastasis was investigated in experimental models. METHODS: The in vitro proapoptotic effects of honokiol on human androgen-dependent and -independent PCa, bone marrow, bone marrow-derived endothelial, and prostate stroma cells were investigated. Honokiol-induced activation of caspases was evaluated by Western blot and FACS analysis. To confirm the cytotoxicity of honokiol, mice bone was inoculated in vivo with androgen-independent PCa, C4-2 cells and the effects of honokiol and/or docetaxel on PCa growth in bone were evaluated. Daily honokiol (100 mg/kg) and/or weekly docetaxel (5 mg/kg) were injected intraperitoneally for 6 weeks. PCa growth in mouse bone was evaluated by radiography, serum prostate-specific antigen (PSA) and tissue immunohistochemistry. RESULTS: Honokiol induced apoptosis in all cell lines tested. In PCa cells honokiol induced apoptosis via the activation of caspases 3, 8, and 9 and the cleavage of poly-adenosine diphosphate ribose polymerase in a dose- and time-dependent manner. Honokiol was shown to inhibit the growth and depress serum PSA in mice harboring C4-2 xenografts in the skeleton and the combination with docetaxel showed additive effects that inhibited further growth without evidence of systemic toxicity. Immunohistochemical staining confirmed honokiol exhibited growth-inhibitory, apoptotic, and antiangiogenic effects on PCa xenografts. CONCLUSIONS: The combination of honokiol and low-dose docetaxel may be used to improve patient outcome in androgen-independent prostate cancer with bone metastasis.

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Publishing Authors By Initials

K Shigemura,JL Arbiser,SY Sun,M Zayzafoon,PA Johnstone,M Fujisawa,A Gotoh,B Weksler,HE Zhau,LW Chung,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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MEDLINE DATE:

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer

VOLUME: 109

Page Numbers: 1279-89

Journal Abbreviation: Cancer

ISSN: 0008-543X

DAY: 1

MONTH: Apr

YEAR: 2007

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374236

Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: drug effects

Chemical & Substance for Abstract: Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Information

Substance Name: Caspases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.

AFFILIATION: Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA098912

ACRONYM: CA

MEDLINETA: Cancer

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