Homology modeling of tubulin: influence predictions for microtubule's biophysical properties.

Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Research Abstract Details 

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Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Abstract Text:

Eric J Carpenter,J Torin Huzil,Richard F ,Jack A Tuszynski,

Using comparative modeling, we have generated structural models of 475 alpha and beta tubulins. Using these models, we observed a global, structural similarity between the tubulin isotypes. However, a number of subtle differences in the isotypes physical properties, including net electric charges, solvent accessible surface areas, and electric dipole moments were also apparent. In order to examine the roles that these properties may play in microtubule (MT) assembly and stability, we have created a model to evaluate the dipole-dipole interaction energies of varying MT lattice conformations, using human tubulin isotypes as particularly important examples. We conclude that the dipole moments of each tubulin isotype may influence their functional characteristics within the cell, resulting in differences for MT assembly kinetics and stability.

Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Publishing Authors By Initials

EJ Carpenter,JT Huzil,RF ,JA Tuszynski,

For similar macromolecular substances: polymers: biopolymers: microtubule proteins: tubulin research abstracts see: macromolecular substances: polymers: biopolymers: microtubule proteins: tubulin research

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Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European biophysics journal : EBJ

VOLUME: 36

Page Numbers: 35-43

Journal Abbreviation: Eur. Biophys. J.

ISSN: 0175-7571

DAY: 29

MONTH: 08

YEAR: 2006

Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8409413

Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Keywords Mesh Terms:

KEYWORDS: Tubulin

MESH TERMS: chemistry

Chemical & Substance for Abstract: Homology modeling of tubulin: influence predictions for microtubule's biophysical properties. Information

Substance Name: Tubulin

Registry Number: 0

Grant and Affiliation Information for Homology modeling of tubulin: influence predictions for microtubule's biophysical properties.

AFFILIATION: Department of Oncology, Division of Experimental Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB, Canada T6G 1Z2.

Country: Germany

AGENCY: United States NCI

GRANT: P30-CA54174

ACRONYM: CA

MEDLINETA: Eur Biophys J

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