Homocysteine and diabetic retinopathy.

Homocysteine and diabetic retinopathy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Homocysteine and diabetic retinopathy. Abstract Text:

Laima Brazionis,Kevin Rowley,Catherine Itsiopoulos,Colin Alexander Harper,Kerin O'Dea,Laima Brazionis,Kevin Rowley,Catherine Itsiopoulos,Colin Alexander Harper,Kerin O'Dea,Laima Brazionis,Kevin Rowley,Catherine Itsiopoulos,Colin Alexander Harper,Kerin O'Dea,Laima Brazionis,Kevin Rowley,Catherine Itsiopoulos,Colin Alexander Harper,Kerin O'Dea,

OBJECTIVE: Homocysteine is an emerging risk factor for cardiovascular and nondiabetic ocular vaso-occlusive diseases. However, studies of the relationship between homocysteine and diabetic retinopathy have reported inconsistent results. The purpose of this study was to evaluate the relationship between plasma total homocysteine concentration and diabetic retinopathy. RESEARCH DESIGN AND METHODS: We assessed the homocysteine-retinopathy relationship in 168 men and women with type 2 diabetes in a community-based, cross-sectional study. We photodocumented diabetic retinopathy status and measured plasma total homocysteine concentration using a commercial fluorescence polarization immunoassay enzymatic kit. Data for selected clinical/demographic variables and established risk factors for diabetic retinopathy were obtained from fasting blood samples and an interviewer-assisted lifestyle questionnaire. RESULTS: A higher mean plasma total homocysteine concentration was observed in diabetic individuals with retinopathy than in those without retinopathy (11.5 mumol/l [95% CI 10.4-12.5] vs. 9.6 mumol/l [9.1-10.2], P = 0.001). Furthermore, the relationship between homocysteine and diabetic retinopathy was not explained by renal dysfunction and was independent of the other major risk factors for diabetic retinopathy (duration of diabetes, A1C, and systolic blood pressure) and determinants of higher homocysteine concentrations (age, sex, and red cell folate) (odds ratio 1.20 [95% CI 1.023-1.41], P = 0.024). CONCLUSIONS: Plasma total homocysteine concentration may be a useful biomarker and/or a novel risk factor for increased risk of diabetic retinopathy in people with type 2 diabetes.

Homocysteine and diabetic retinopathy. Publishing Authors By Initials

L Brazionis,K Rowley,C Itsiopoulos,CA Harper,K O'Dea,L Brazionis,K Rowley,C Itsiopoulos,CA Harper,K O'Dea,L Brazionis,K Rowley,C Itsiopoulos,CA Harper,K O'Dea,L Brazionis,K Rowley,C Itsiopoulos,CA Harper,K O'Dea,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Homocysteine and diabetic retinopathy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Diabetes care

VOLUME: 31

Page Numbers: 50-6

Journal Abbreviation: Diabetes Care

ISSN: 1935-5548

DAY: 26

MONTH: 09

YEAR: 2007

Homocysteine and diabetic retinopathy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7805975

Homocysteine and diabetic retinopathy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Homocysteine and diabetic retinopathy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Homocysteine and diabetic retinopathy.

AFFILIATION: Department of Medicine, University of Melbourne, St. Vincent's Hospital, P.O. Box 2900, Fitzroy, Victoria 3065, Australia. laimab@medstv.unimelb.edu.au.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Diabetes Care

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Homocysteine and diabetic retinopathy Related Publications

• 5-Bromo-2-deoxyuridine activates DNA damage signalling responses and induces a senescence-like phenotype in p16-null lung cancer cells.
• A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects.
• BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells.
• Evaluating broiler growth and mortality in chicks with minor navel conditions at hatching.
• Gender, ethnicity, culture and social class influences on childhood obesity among Australian schoolchildren: implications for treatment, prevention and community education.
• Homocysteine and diabetic retinopathy.
• Is there a role for monounsaturated fat in the dietary management of obesity?
• Monounsaturated fat rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects: response to Paniagua et al.
• Pharmacokinetics and Safety of ABT-578, a Sirolimus (Rapamycin) Analogue, after Single Intravenous Bolus Injection in Healthy Male Volunteers.
• Plasminogen activator inhibitor-1 activity in type 2 diabetes: a different relationship with coronary heart disease and diabetic retinopathy.
• Prevention programs for body image and eating disorders on University campuses: a review of large, controlled interventions.
• Recombinant LH (lutropin alfa) for the treatment of hypogonadotrophic women with profound LH deficiency: a randomized, double-blind, placebo-controlled, proof-of-efficacy study.
• Recombinant human luteinizing hormone, lutropin alfa, for the induction of follicular development and pregnancy in profoundly gonadotrophin-deficient women.
• Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods.