Homocysteine and abdominal aortic aneurysms.

Homocysteine and abdominal aortic aneurysms. Research Abstract Details 

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Homocysteine and abdominal aortic aneurysms. Abstract Text:

Paul Moroz,Max T Q Le,Paul E Norman,

There is evidence to suggest that increased levels of homocysteine play a significant role in vascular disease. It has been suggested that lowering homocysteine levels by dietary folate supplementation may reduce the risk of stroke and coronary heart disease. It is plausible that homocysteine may also play a role in the pathogenesis of abdominal aortic aneurysms (AAA) and that patients with this disease may benefit from folate supplementation. Our objective was to review the published work with regard to the role of homocysteine in the pathogenesis of AAA. Searches were carried out in published work in English with the keywords 'abdominal aortic aneurysm' and 'homocysteine'. There is evidence from in vitro and animal model studies that activation of metalloproteinases by homocysteine can influence aortic wall structure. Several case-control studies report an association between increased levels of homocysteine and the presence of an AAA. There are conflicting genotypic data concerning the association between methylenetetrahydrofolate reductase gene variants and AAA. Although there is evidence for an association between homocysteine and AAA, it is not strong enough to conclude that it plays a causal role in the pathogenesis of AAA. Further research is needed, given the potential benefit that simple vitamin supplementation may have for patients with AAA.

Homocysteine and abdominal aortic aneurysms. Publishing Authors By Initials

P Moroz,MT Le,PE Norman,

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Homocysteine and abdominal aortic aneurysms. Journal Published:

PUBLICATION TYPE: Review

Journal: ANZ journal of surgery

VOLUME: 77

Page Numbers: 329-32

Journal Abbreviation:

ISSN: 1445-1433

DAY: 3

MONTH: May

YEAR: 2007

Homocysteine and abdominal aortic aneurysms. Information

Number of References: 39

LANGUAGE: eng

NlmUniqueID: 101086634

Homocysteine and abdominal aortic aneurysms. Keywords Mesh Terms:

KEYWORDS: Methylenetetrahydrofolate Reductase (NAD

MESH TERMS: metabolism

Chemical & Substance for Abstract: Homocysteine and abdominal aortic aneurysms. Information

Substance Name: Metalloproteases

Registry Number: EC 3.4.-

Grant and Affiliation Information for Homocysteine and abdominal aortic aneurysms.

AFFILIATION: School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, Perth, Western Australia, Australia.

Country: Australia

AGENCY: United States NHLBI

GRANT: R01 HL080010-01

ACRONYM: HL

MEDLINETA: ANZ J Surg

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