Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA.

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Research Abstract Details 

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Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Abstract Text:

Matthew E Klein,Daniel T Lioy,Lin Ma,Soren Impey,Gail Mandel,Richard H Goodman,Matthew E Klein,Daniel T Lioy,Lin Ma,Soren Impey,Gail Mandel,Richard H Goodman,

Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Publishing Authors By Initials

ME Klein,DT Lioy,L Ma,S Impey,G Mandel,RH Goodman,ME Klein,DT Lioy,L Ma,S Impey,G Mandel,RH Goodman,

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Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature neuroscience

VOLUME: 10

Page Numbers: 1513-4

Journal Abbreviation: Nat. Neurosci.

ISSN: 1097-6256

DAY: 11

MONTH: 11

YEAR: 2007

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Information

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LANGUAGE: eng

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AFFILIATION: Vollum Institute, Oregon Health & Science University L-474, 3181 SW Sam Jackson Rd., Portland, Oregon 97239, USA.

Country: United States

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MEDLINETA: Nat Neurosci

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