Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status.

Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Research Abstract Details 

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Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Abstract Text:

Kristina M von Castel-Roberts,Anne Louise Morkbak,Ebba Nexo,Claire A Edgemon,David R Maneval,Jonathan J Shuster,John F Valentine,Gail P A Kauwell,Lynn B Bailey,

BACKGROUND: It has been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be used to assess absorption. To develop a reliable clinical absorption test that uses holo-TC, it is necessary to determine the optimal timeline for vitamin B-12 administration and postdose assessment. OBJECTIVE: The objective of this study was to assess the magnitude and patterns of change in the postabsorption response of holo-TC to oral vitamin B-12. DESIGN: Adult (18-49 y) male and female participants (n = 21) with normal vitamin B-12 status were given three 9-mug doses of vitamin B-12 at 6-h intervals beginning early morning (baseline) on day 1. Blood was drawn at 17 timed intervals over the course of 3 d for the analysis of holo-TC and other indicators of vitamin B-12 status. RESULTS: Mean holo-TC increased significantly (P < 0.001) from baseline at 6 h (11%) and 24 h (50%). TC saturation increased significantly (P < 0.001) from baseline at 12.5 h (33%) and 24 h (50%). The mean cobalamin concentration changed significantly (P < 0.001) from baseline at 24 h (15%) and 48 h (14%). The ratio of holo-TC to cobalamin increased significantly (P < 0.001) at 24 h (32%). CONCLUSIONS: The greatest increase in holo-TC was observed 24 h after ingestion of three 9-mug doses of vitamin B-12. Our results indicate that a vitamin B-12 absorption test based on measurement of holo-TC after administration of three 9-mug doses of vitamin B-12 should run for 24 h.

Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Publishing Authors By Initials

KM von Castel-Roberts,AL Morkbak,E Nexo,CA Edgemon,DR Maneval,JJ Shuster,JF Valentine,GP Kauwell,LB Bailey,

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: growth substances: micronutrients: vitamins: vitamin b complex research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: growth substances: micronutrients: vitamins: vitamin b complex research

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Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of clinical nutrition

VOLUME: 85

Page Numbers: 1057-61

Journal Abbreviation:

ISSN: 0002-9165

DAY: 3

MONTH: Apr

YEAR: 2007

Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376027

Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Keywords Mesh Terms:

KEYWORDS: Vitamin B Complex

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status. Information

Substance Name: Vitamin B 12

Registry Number: 68-19-9

Grant and Affiliation Information for Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status.

AFFILIATION: Departments of Food Science and Human Nutrition, University of Florida, Gainesville, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01 RR00082

ACRONYM: RR

MEDLINETA: Am J Clin Nutr

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