HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant.

HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant. Research Abstract Details 

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HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant. Abstract Text:

Chronic renal failure (CRF) leads in the majority of instances to end-stage renal disease (ESRD) requiring renal replacement therapy. Age, gender, genetics, race, hypertension, and smoking among others are factors associated with ESRD. Our interest was to evaluate the possible associations of class I and II HLA antigens with ESRD renal disease independent of other factors, among patients with CRF, having various diagnoses in the Brazilian population of the São Paulo state. So 21 HLA-A, 31 HLA-B, and 13 HLA-DR were detected in 105 patients who were compared with 160 healthy controls of both sexes who were not related to the patients evaluated until 2005. We calculated allelic frequencies, haplotypes frequencies, etiological fractions (EF), preventive fractions, and relative risks (RR). We compared demographic data of patients and controls. The antigens positively associated with ESRD were: HLA-A78 (RR = 30.31 and EF = 0.96) and HLA-DR11 (RR = 18.87 and EF = 0.65). The antigens HLAB14 (RR = 29.90 and EF = 0.75) was present at a significantly lower frequency among patients compared with controls. In contrast, no haplotype frequency showed statically significant associations. Further molecular studies may clarify types and subtypes of alleles involved with ESRD progression.

HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant. Publishing Authors By Initials

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HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplantation proceedings

VOLUME: 40

Page Numbers: 1333-6

Journal Abbreviation: Transplant. Proc.

ISSN: 0041-1345

DAY: 30

MONTH: Jun

YEAR: 2008

HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant. Information

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LANGUAGE: eng

NlmUniqueID: 243532

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Grant and Affiliation Information for HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant.

AFFILIATION: Department of Biochemistry and Immunology, FMRP-USP, Ribeirão Preto, Brazil.

Country: United States

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MEDLINETA: Transplant Proc

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