HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu.

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Abstract Text:

Hai-Xia Cao,Li Zhao,Lan-Xia Zhou,

The study was aimed to explore the possible association between HLA-DRB1 allele polymorphism and the susceptibility to leukemia in Gansu Chinese Han nationality and to find the genes susceptible to leukemia. HLA-DRB1 genes in 74 patients with leukemia from northwestern China and 82 healthy Chinese controls were determined by polymerase chain reaction and sequence-specific oligonucleotide probe hybridizations (PCR/SSO) DNA analysis. The results showed that as compared with control, the allele frequencies of HLA-DRB1*03 (chi(2) = 8.125, P = 0.004), HLA-DRB1*07 (chi(2) = 13.526, P = 0.000), HLA-DRB1*08 (chi(2) = 18.855, P = 0.000), HLA-DRB1*13 (chi(2) = 7.039, P = 0.008) significantly increased in AML group. The allele frequencies of HLA-DRB1*07 (chi(2) = 5.689, P = 0.017), HLA-DRB1*11 (chi(2) = 7.73, P = 0.005), HLA-DRB1*12 (chi(2) = 4.234, P = 0.040), HLA-DRB1*13 (chi(2) = 38.333, P = 0.000) significantly increased in CML group. The allele frequency of HLA-DRB1*01 (chi(2) = 5.294, P = 0.021) significantly increased in ALL group. It is concluded that the susceptibility to AML in Gansu Han nationality is positively related to HLA-DRB1*03. 1*07.1*08.1*13. CML positively correlates with HLA-DRB1*07. 1*11.1*12.1*13, and ALL may be positively in relation with HLA-DRB1*01. Allele polymorphism is associated with the leukemia occurrence.

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Publishing Authors By Initials

HX Cao,L Zhao,LX Zhou,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing

VOLUME: 13

Page Numbers: 788-92

Journal Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za

ISSN: 1009-2137

DAY: 5

MONTH: Oct

YEAR: 2005

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101084424

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. Information

Substance Name: HLA-DRB1 antigen

Registry Number: 128338-86-3

Grant and Affiliation Information for HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu.

AFFILIATION: Department of Hematology, Qinghai Maternity and Children Hospital, Xining 810007, China. caohx71@sina.com

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhongguo Shi Yan Xue Ye Xue Za

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu Related Publications

• Inhibitors of Na+/H+ and Na+/Ca2+ exchange depress intracellular calcium elevation induced by ischemia/reperfusion in rat cardiac myocytes.
• Inhibitory effect of recombinant FN polypeptide CH50 on the metastasis and tumor growth.
• Quantification of bcr/abl mRNA expression level in leukemia cells by FQ-RT-PCR.
• [An experimental study on the survival of the anterior abdominal skin flap after VEGF cDNA administration]
• [An inquiry into blood loss in laparoscopic liver resections]
• [Association studies of dopamine D4 receptor gene and dopamine transporter gene polymorphisms in Han Chinese patients with attention deficit hyperactivity disorder]
• [Beneficial effect of thyrotropin-releasing hormone in combination with HSD on hemorrhagic shock with pulmonary edema at high altitude in the rat]
• [Changes in platelet membrane glycoprotein levels in patients with cardiopulmonary resuscitation]
• [Clinical analysis of 13 infected total knee replacements]
• [Detection of epileptic waves in EEG based on wavelet transform]
• [Effects of Alexandrium tamarense and Prorocentrum donghaiense on rotifer Brachionus plicatilis population]
• [Effects of the novel gene, LAPTM4B, highly expression in hepatocellular carcinoma on cell proliferation and tumorigenesis of NIH3T3 cells]
• [Experimental study of K562 cell apoptosis induced by harringtonine]
• [Expression of otsA gene in tobacco and improvement stress tolerance]
• [Hemodynamic and pathologic changes in open abdominal wound after seawater immersion in dog]
• [High efficient expression of recombinant human platelet factor IV in pichia pastoris]
• [Identification of radix Rubiae and the root of Humulus scardens (Lour.) Merr.]
• [Incompatibility among indigenous plasmids of Sinorhizobium fredii strains and its application for plasmid curing]
• [Nutrition support of severe illness patients of general surgery during perioperation period]
• [Preliminary analysis of the characteristics of red tide areas in Changjiang River estuary and its adjacent sea]
• [Relationship between tissue inhibitors of metalloproteinase and metastasis and prognosis in breast cancer]
• [Repairing large alar defects by using a retro-grade auricular flap]
• [Research advance in effects of harmful algal bloom species on zooplankton]
• [Scoring protocol for quantitative diagnosis of gastrointestinal dysfunction and failure in severe cases]
• [Study on new techniques for genetic diagnosis of deletional alpha-thalassemia]
• [The influence of intrahepatic transplantation of hepatocytes and insular cells on liver cirrhosis]
• [The relationship of facet orientation to intervertebral disc protrusion and lateral recess stenosis in lower lumbar spine]
• [Transplantation of bone marrow cells upregulated vascular endothelial growth factor and its receptor and improved ischemic myocardial function]
• [Ultrasound surveillance of cervical lymph node metastasis in thoracic esophageal carcinoma]
• [Using scar tissue flap to repair secondary nasal deformities of unilateral cleft lip]