HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors.

HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors. Research Abstract Details 

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HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors. Abstract Text:

Ke-Ming Du,Yun Ji,Jun-Hua Xie,Min Fu,Ying Sun,Ye Jin,Ji-Li Sun,Jian-Hao Yang,Zheng Zhang,Zhen Mao,Da-Zhuang Liu,Kai-Cheng Qian,Tong-Mao Zhao,Ke-Ming Du,Yun Ji,Jun-Hua Xie,Min Fu,Ying Sun,Ye Jin,Ji-Li Sun,Jian-Hao Yang,Zheng Zhang,Zhen Mao,Da-Zhuang Liu,Kai-Cheng Qian,Tong-Mao Zhao,

HLA phenotypes of 26,266 Chinese individuals who were recruited as potential hematopoietic stem cell donors by the Shanghai Red Cross Marrow Donor Registry, part of the China Marrow Donor Program, were determined for HLA-A, -B, and -DRB1 alleles at low to intermediate resolution using DNA-based typing methods. The large sample size of the study allowed accurate calculation of the Chinese HLA haplotype frequencies. The observed alleles correspond to 19 HLA-A, 44 -B, and 13 -DR split antigens. The serologic equivalents of HLA-A36, -A80, -B78, and -DR18 alleles were not observed. A total of 2,241 distinct HLA-A, -B, -DRB1 haplotypes were identified. Three-locus haplotype frequency was estimated using the maximum likelihood method. The lowest haplotype frequency that can be reliably estimated at a 95% confidence level was 0.000057. Using this cutoff value, 1,220 haplotypes (54%) were statistically reliable and their cumulative haplotype frequency was 0.9730. The cumulative haplotype frequency of the remaining 1,021 haplotypes (46%) was 0.0270. A regression equation of p = 0.192 log N - 0.576 was derived to estimate the probability (p) of finding an HLA-A, -B, -DR split antigens-matched donor in a pool of N Chinese donors.

HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors. Publishing Authors By Initials

KM Du,Y Ji,JH Xie,M Fu,Y Sun,Y Jin,JL Sun,JH Yang,Z Zhang,Z Mao,DZ Liu,KC Qian,TM Zhao,KM Du,Y Ji,JH Xie,M Fu,Y Sun,Y Jin,JL Sun,JH Yang,Z Zhang,Z Mao,DZ Liu,KC Qian,TM Zhao,

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HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Human immunology

VOLUME: 68

Page Numbers: 854-66

Journal Abbreviation: Hum. Immunol.

ISSN: 0198-8859

DAY: 24

MONTH: 05

YEAR: 2007

HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors. Information

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LANGUAGE: eng

NlmUniqueID: 8010936

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Grant and Affiliation Information for HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors.

AFFILIATION: Shanghai Blood Center, Shanghai, China. dkeming@hotmail.com

Country: United States

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MEDLINETA: Hum Immunol

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