HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G.

HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G. Research Abstract Details 

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HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G. Abstract Text:

Mercedes Muñoz-Nieto,Lucía Pérez-Alvarez,Miguel Thomson,Valentina García,Antonio Ocampo,Gema Casado,Elena Delgado,Celia Miralles,Elena V Zquez de Parga,María Sierra,Gerardo Contreras,Rafael Nájera,Mercedes , ,Miguel Thomson,Valentina ,Antonio Ocampo,Gema Casado,Elena Delgado,Celia Miralles, de Parga, Sierra,Gerardo Contreras,Rafael ,

ABSTRACT The aim of this study was to characterize the HIV-1 intersubtype recombinant forms generated during the follow-up of a dual natural infection with subtypes B and G. Near full-length sequences from plasma and peripheral blood mononuclear cell (PBMC) compartments were analyzed and the biological characteristics of their derived primary isolates studied. Different mutations were detected in V1, V2, and V3 sequences from primary isolates but not in sequences from plasma RNA or PBMC DNA. The HIV-1 near full-length sequence from the first collected plasma was of subtype G and the presence of subpopulations of subtypes B and G was observed with subtype-specific primers for protease and reverse transcriptase segments. Subsequent sequences from plasma, PBMCs, and primary isolates were obtained during a follow-up of 6 years; all of them were BG recombinants and showed identical intersubtype breakpoints between subtypes B and G in pol and nef. The env sequence from all primary isolates harbored a unique insert of subtype B. Specific primers for the V3 loop identified fluctuating subtype B and/or subtype G sequences either from plasma RNA or PBMC DNA.

HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G. Publishing Authors By Initials

M Muñoz-Nieto,L Pérez-Alvarez,M Thomson,V García,A Ocampo,G Casado,E Delgado,C Miralles,EV de Parga,M Sierra,G Contreras,R Nájera,M ,L ,M Thomson,V ,A Ocampo,G Casado,E Delgado,C Miralles,EV de Parga,M Sierra,G Contreras,R ,

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HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AIDS research and human retroviruses

VOLUME: 24

Page Numbers: 337-43

Journal Abbreviation: AIDS Res. Hum. Retroviruses

ISSN: 0889-2229

DAY: 20

MONTH: Feb

YEAR: 2008

HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G. Information

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LANGUAGE: eng

NlmUniqueID: 8709376

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AFFILIATION: Area de Patogenia Viral, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.

Country: United States

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MEDLINETA: AIDS Res Hum Retroviruses

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