HIV Neurotoxicity: Potential Therapeutic Interventions.

HIV Neurotoxicity: Potential Therapeutic Interventions. Research Abstract Details 

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HIV Neurotoxicity: Potential Therapeutic Interventions. Abstract Text:

David R Wallace,

Individuals suffering from human immunodeficiency virus type 1 (HIV-1) infection suffer from a wide range of neurological deficits. The most pronounced are the motor and cognitive deficits observed in many patients in the latter stages of HIV infection. Gross postmortem inspection shows cortical atrophy and widespread neuronal loss. One of the more debilitating of the HIV-related syndromes is AIDS-related dementia, or HAD. Complete understanding of HIV neurotoxicity has been elusive. Both direct and indirect toxic mechanisms have been implicated in the neurotoxicity of the HIV proteins, Tat and gp120. The glutamatergic system, nitric oxide, calcium, oxidative stress, apoptosis, and microglia have all been implicated in the pathogenesis of HIV-related neuronal degeneration. The aim of this review is to summarize the most recent work and provide an overview to the current theories of HIV-related neurotoxicity and potential avenues of therapeutic interventions to prevent the neuronal loss and motor/cognitive deficits previously described.

HIV Neurotoxicity: Potential Therapeutic Interventions. Publishing Authors By Initials

DR Wallace,

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HIV Neurotoxicity: Potential Therapeutic Interventions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedicine & biotechnology

VOLUME: 2006

Page Numbers: 65741

Journal Abbreviation: J. Biomed. Biotechnol.

ISSN: 1110-7243

DAY: 18

MONTH: 10

YEAR: 2006

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LANGUAGE: eng

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Country: United States

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