HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features.

HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Research Abstract Details 

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HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Abstract Text:

Fusheng Li,Helen Horton,Peter B Gilbert,Juliana M McElrath,Lawrence Corey,Steve G Self,

Much of the current effort in HIV-1 vaccine design is directed at achieving T-cell immunity that will result in enough immunological memory to contain HIV-1 infection after acquisition. However, antigenic diversity, plus a lack of understanding of HIV-1 vaccine immunology, have hindered the development of a globally effective cytotoxic T-lymphocyte (CTL)-based vaccine. Cellular response, in using a finite immune system to recognize an infinite number of potential pathogens, exhibits a series of parsimonious features. These features are considered critical in modulating HIV-1 vaccine multiple specificities. We took the features into consideration when the potential epitope coverage (E(c)) to circulating strains by current vaccine strategies was analyzed. Based on these analyses, several approaches are proposed to enhance the breadth of vaccine responses and, hence, the potential protective efficacy.

HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Publishing Authors By Initials

F Li,H Horton,PB Gilbert,JM McElrath,L Corey,SG Self,

For similar therapeutics: biological therapy: immunotherapy: immunization: immunotherapy, active: vaccination research abstracts see: therapeutics: biological therapy: immunotherapy: immunization: immunotherapy, active: vaccination research

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MEDLINE DATE:

HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Current HIV research

VOLUME: 5

Page Numbers: 97-107

Journal Abbreviation: Curr. HIV Res.

ISSN: 1873-4251

DAY: 3

MONTH: Jan

YEAR: 2007

HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101156990

HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Keywords Mesh Terms:

KEYWORDS: Vaccination

MESH TERMS: immunology

Chemical & Substance for Abstract: HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features. Information

Substance Name: Epitopes

Registry Number: 0

Grant and Affiliation Information for HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features.

AFFILIATION: Statistical Center for HIV/AIDS Research and Prevention, 1100 Fairview Avenue N, Seattle, WA 98109, USA. Fusheng@scharp.org.

Country: Netherlands

AGENCY: United States NIAID

GRANT: 5U1AI046703-05

ACRONYM: AI

MEDLINETA: Curr HIV Res

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