Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons.

Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons. Research Abstract Details 

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Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons. Abstract Text:

E K Stauffer,J C McDonagh,T G Hornby,R M Reinking,D G Stuart,

In mammalian spinal motoneurons (MNs), the slow component of the afterhyperpolarization (AHP) that follows the spike of each action potential is a major but not the sole determinant of the cells' firing rate. In this brief historical review, we emphasize four points about the AHP-firing rate relation. (1) There is a relatively sparse literature across vertebrates that directly addresses this topic. (2) After the advent of intracellular recording in the early 1950s, there was evidence from mammals to the contrary of an idea that subsequently became prevalent: that the high-firing rates attainable by spinal interneurons (INs) and low-threshold MNs was attributable to their small AHP at rheobase. (3) Further work is needed to determine whether our present findings on the AHP-firing rate relation of turtle cells generalize to the spinal neurons of other vertebrate species. (4) Relevant to point 3, substantial in vivo and in vitro work is potentially available in raw data used in reports on several mammalian and non-mammalian vertebrates. In summary, the factors in addition to the slow AHP that help determine spinal INs and MN firing rate deserve further evaluation across vertebrates, with relevant data already potentially available in several laboratories.

Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons. Publishing Authors By Initials

EK Stauffer,JC McDonagh,TG Hornby,RM Reinking,DG Stuart,

For similar nervous system: central nervous system: spinal cord research abstracts see: nervous system: central nervous system: spinal cord research

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Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of comparative physiology. A, Neuroetholog

VOLUME: 193

Page Numbers: 145-58

Journal Abbreviation: J. Comp. Physiol. A Neuroethol

ISSN: 0340-7594

DAY: 28

MONTH: 12

YEAR: 2006

Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons. Information

Number of References: 113

LANGUAGE: eng

NlmUniqueID: 101141792

Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons. Keywords Mesh Terms:

KEYWORDS: Spinal Cord

MESH TERMS: physiology

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Grant and Affiliation Information for Historical reflections on the afterhyperpolarization--firing rate relation of vertebrate spinal neurons.

AFFILIATION: Department of Physiology and Pharmacology, The University of Minnesota, Duluth, MN 55812-3031, USA.

Country: Germany

AGENCY: United States NINDS

GRANT: NS 20762

ACRONYM: NS

MEDLINETA: J Comp Physiol A Neuroethol Se

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