[Histopathological features of 27 cases of primary biliary cirrhosis]

[Histopathological features of 27 cases of primary biliary cirrhosis] Research Abstract Details 

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[Histopathological features of 27 cases of primary biliary cirrhosis] Abstract Text:

Xiaoyan Shi,Changhuai Zhang,Jidong Jia,Fukui Zhang,Linxue Qian,Baoen Wang,

OBJECTIVE: To explore the clinical and histopathological features of primary biliary cirrhosis (PBC). METHODS: The clinical, laboratory, as well as histological features of 27 cases of PBC were retrospectively analyzed. RESULTS: The male to female ratio was 1:8 (3:24), aged from 22 to 69 years. The main clinical manifestations included: fatigue (62.9%, 17/27), jaundice (59.2%, 16/27) and pruritus (29.6%, 8/27), with all of patients having markedly elevated serum alkaline phosphatase and gamma-glutamyl transpeptidase and 95.8% (23/27) of the patients being positive for anti-mitochondrial antibody (AMA). The main histopathological changes were: necroinflammation of interlobular bile ducts (100%, 27/27), lymphocyte aggregation or lymphocyte follicles (15%, 4/27), granuloma (26%, 7/27), decreased number of interlobular bile ducts and smaller bile duct proliferation (55%, 15/27), feathery degeneration of hepatocytes (59%, 16/27); bilirubinostasis in hepatocytes and/or canaliculi (52%, 14/27); fibrosis and distortion of lobules (26%, 7/27), pseudolobular formation (11%, 3/27). CONCLUSIONS: The main clinical features of PBS are fatigue and pruritus, markedly elevated phosphatase and gamma-glutamyl transpeptidase, and positive AMA with or without jaundice. Its histopathological hallmarks are (1)necroinflammmation and ductopenia involved mainly in interlobular bile ducts; (2)lymphocyte aggregation, granuloma formation and bile ductular proliferation in the portal area; and (3)feathery degeneration of hepatocytes.

[Histopathological features of 27 cases of primary biliary cirrhosis] Publishing Authors By Initials

X Shi,C Zhang,J Jia,F Zhang,L Qian,B Wang,

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[Histopathological features of 27 cases of primary biliary cirrhosis] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbi

VOLUME: 10

Page Numbers: 338-40

Journal Abbreviation: Zhonghua Gan Zang Bing Za Zhi

ISSN: 1007-3418

DAY: 23

MONTH: Oct

YEAR: 2002

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LANGUAGE: chi

NlmUniqueID: 9710009

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AFFILIATION: Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China.

Country: China

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MEDLINETA: Zhonghua Gan Zang Bing Za Zhi

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