Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease.

Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. Research Abstract Details 

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Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. Abstract Text:

Shin Kariya,Sebahattin Cureoglu,Hisaki Fukushima,Takeshi Kusunoki,Patricia A Schachern,Kazunori Nishizaki,Michael M Paparella,Shin Kariya,Sebahattin Cureoglu,Hisaki Fukushima,Takeshi Kusunoki,Patricia A Schachern,Kazunori Nishizaki,Michael M Paparella,Shin Kariya,Sebahattin Cureoglu,Hisaki Fukushima,Takeshi Kusunoki,Patricia A Schachern,Kazunori Nishizaki,Michael M Paparella,

HYPOTHESIS: To disclose the histopathologic findings in the contralateral temporal bone in unilateral Ménière's disease. BACKGROUND: Several functional studies reported abnormal findings in the contralateral ears in patients with unilateral Ménière's disease. METHODS: This study involved quantitative analysis, including the number of spiral ganglion cells, the loss of cochlear hair cells, the area of stria vascularis, and the density of fibrocytes in the spiral ligament. It included 14 temporal bones from 7 subjects with bilateral Ménière's disease, 30 temporal bones from 15 subjects with unilateral Ménière's disease, and 17 age-matched normal control temporal bones from 12 subjects. RESULTS: The mean number of spiral ganglion cells in the contralateral temporal bones in patients with unilateral Ménière's disease was 17,376.0 and was significantly lower than that in normal controls. The mean loss of inner and outer hair cells in the contralateral temporal bones in patients with unilateral Ménière's disease was significantly greater than that in normal controls in all turns. The stria vascularis was severely atrophic and degenerated in patients with Ménière's disease. The mean area of stria vascularis in contralateral temporal bones in patients with unilateral Ménière's disease was significantly smaller than normal controls. There was no significant difference in the density of fibrocytes in the spiral ligament between the diseased side and the contralateral side in patients with unilateral Ménière's disease and between normal control and contralateral side. CONCLUSION: The contralateral inner ear in patients with unilateral Ménière's disease has significantly more damage compared with inner ears of normal controls.

Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. Publishing Authors By Initials

S Kariya,S Cureoglu,H Fukushima,T Kusunoki,PA Schachern,K Nishizaki,MM Paparella,S Kariya,S Cureoglu,H Fukushima,T Kusunoki,PA Schachern,K Nishizaki,MM Paparella,S Kariya,S Cureoglu,H Fukushima,T Kusunoki,PA Schachern,K Nishizaki,MM Paparella,

For similar musculoskeletal system: skeleton: bone and bones: skull: temporal bone research abstracts see: musculoskeletal system: skeleton: bone and bones: skull: temporal bone research

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Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Otology & neurotology : official publication of th

VOLUME: 28

Page Numbers: 1063-8

Journal Abbreviation: Otol. Neurotol.

ISSN: 1531-7129

DAY: 8

MONTH: Dec

YEAR: 2007

Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. Information

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LANGUAGE: eng

NlmUniqueID: 100961504

Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. Keywords Mesh Terms:

KEYWORDS: Temporal Bone

MESH TERMS: pathology

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Grant and Affiliation Information for Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease.

AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Country: United States

AGENCY: United States NIDCD

GRANT: P30DC04660

ACRONYM: DC

MEDLINETA: Otol Neurotol

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