Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot.

Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot. Research Abstract Details 

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Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot. Abstract Text:

S Sato,M Nakasato,H Suzuki,T Akiba,H Komatsu,H Orita,M Fukasawa,K Hayasaka,

Balloon pulmonary valvuloplasty (BPV) has been applied to tetralogy of Fallot (TOF) as a palliative procedure. To investigate the histopathologic changes by BPV in the infundibular septum of TOF, we performed histopathologic examinations of the infundibular septum resected at corrective surgery. The subjects were 5 patients with TOF, who underwent BPV at the median age of 2.2 months and the corrective surgery at the median age of 15.0 months (BPV group), and 4 patients with TOF who had no prior BPV and who underwent the corrective surgery at the median age of 14.5 months (control group). There was no significant difference between the two groups in the endocardial thickness, myocardial vacuole degeneration, or fraction of fibrous and interstitial space. However, the specimens from 3 patients in the BPV group had localized dense fibrous lesions in the myocardium. The findings in this limited sample suggest that BPV for TOF does not produce overall histopathologic alterations such as fibrosis, thick endocardium, and myocardial vacuole degeneration, but may sometimes damage the myocardium of the infundibular septum resulting in the formation of localized dense fibrous lesions. The clinical significance of this damage is still unknown, and further cases should be investigated.

Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot. Publishing Authors By Initials

S Sato,M Nakasato,H Suzuki,T Akiba,H Komatsu,H Orita,M Fukasawa,K Hayasaka,

For similar cardiovascular diseases: cardiovascular abnormalities: heart defects, congenital: tetralogy of fallot research abstracts see: cardiovascular diseases: cardiovascular abnormalities: heart defects, congenital: tetralogy of fallot research

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MEDLINE DATE: 1998 Mar-Apr

Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric cardiology

VOLUME: 19

Page Numbers: 155-60

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot. Keywords Mesh Terms:

KEYWORDS: Tetralogy of Fallot

MESH TERMS: therapy

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Grant and Affiliation Information for Histopathologic changes in the infundibular septum after balloon pulmonary valvuloplasty in tetralogy of Fallot.

AFFILIATION: Department of Pediatrics, Yamagata University School of Medicine, Japan.

Country: UNITED STATES

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MEDLINETA: Pediatr Cardiol

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