[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C]

[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C] Research Abstract Details 

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[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C] Abstract Text:

Maja Jovanovi?,Ljiljana Konstantinovi?,Vuka Kati?,Slavisa Ciri?,Velimir Kosti?,Branislav Jovanovi?,

BACKGROUND: The presence of lymphocytes within the liver parenchyma is related to immunologically mediated liver damage in chronic hepatitis C. The aim of the study was to make histological, histochemical, and immunocytochemical assessment of liver biopsy specimens in patients with chronic hepatitis C virus (HCV) infection. METHODS: Biopsy specimens of 20 patients with chronic HCV disease were analyzed, using standard staining procedures to verify histologic liver lesions, as well as immunoenzymatic staining with monoclonal antibodies to detect CD4+ T-lymphocytes, B-lymphocytes, and macrophages. RESULTS: Micromorphologic characteristics of chronic active viral hepatitis C were present in all the patients, differing, however, by the level of their activity. Dominant changes were found within the portal space, consisting of mononuclear lympho-plasmocytic infiltration and macrophages. Immunocytochemical investigation of mononuclear and macrophageal infiltration showed the correlation between micromorphological findings and the degree of the activity. CONCLUSION: The presence of lymphocytic and macrophageal infiltration within the hepatic tissue directly correlated with the intensity of the liver damage. Analysis of the population of cellular infiltrate in the liver together with the monitoring of viremia level and the level of hepatocyte necrosis, could be useful tools for elucidation of the pathogenesis of chronic hepatitis C.

[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C] Publishing Authors By Initials

M Jovanovi?,L Konstantinovi?,V Kati?,S Ciri?,V Kosti?,B Jovanovi?,

For similar persons: age groups: adult: middle aged research abstracts see: persons: age groups: adult: middle aged research

PUBMED ID PMID:

MEDLINE DATE: 2004 Jan-Feb

[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vojnosanitetski pregled. Military-medical and phar

VOLUME: 61

Page Numbers: 29-34

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ISSN: 0042-8450

DAY: 9

MONTH: 01

YEAR: 2008

[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C] Information

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LANGUAGE: scc

NlmUniqueID: 21530700

[Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C] Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: pathology

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Grant and Affiliation Information for [Histopathologic and immunocytochemical changes in the liver in patients with chronic hepatitis C]

AFFILIATION: Klinicki centar-Nis, Klinika za zarazne bolesti, Nis. pedjaj@bankerinter.net

Country: Yugoslavia

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MEDLINETA: Vojnosanit Pregl

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