Histones and histone modifications in protozoan parasites.

Histones and histone modifications in protozoan parasites. Research Abstract Details 

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Histones and histone modifications in protozoan parasites. Abstract Text:

William J Sullivan,Arunasalam Naguleswaran,Sergio O Angel,

Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses. Consequently, two key aspects of virulence that underlie pathogenesis are parasite differentiation and antigenic variation, both of which require changes in the expressed genome. Complicating these requisite alterations in the parasite transcriptome is chromatin, which serves as a formidable barrier to DNA processes including transcription, repair, replication and recombination. Considerable progress has been made in the study of chromatin dynamics in other eukaryotes, and there is much to be gained in extending these analyses to protozoan parasites. Much of the work completed to date has focused on histone acetylation and methylation in the apicomplexans and trypanosomatids. As we describe in this review, such studies provide a unique vantage point of the evolutionary picture of eukaryotic cell development, and reveal unique phenomena that could be exploited pharmacologically to treat protozoal diseases.

Histones and histone modifications in protozoan parasites. Publishing Authors By Initials

WJ Sullivan,A Naguleswaran,SO Angel,

For similar parasitic diseases: protozoan infections research abstracts see: parasitic diseases: protozoan infections research

PUBMED ID PMID:

MEDLINE DATE:

Histones and histone modifications in protozoan parasites. Journal Published:

PUBLICATION TYPE: Review

Journal: Cellular microbiology

VOLUME: 8

Page Numbers: 1850-61

Journal Abbreviation: Cell. Microbiol.

ISSN: 1462-5814

DAY: 4

MONTH: 10

YEAR: 2006

Histones and histone modifications in protozoan parasites. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883691

Histones and histone modifications in protozoan parasites. Keywords Mesh Terms:

KEYWORDS: Protozoan Infections

MESH TERMS: therapy

Chemical & Substance for Abstract: Histones and histone modifications in protozoan parasites. Information

Substance Name: Histones

Registry Number: 0

Grant and Affiliation Information for Histones and histone modifications in protozoan parasites.

AFFILIATION: Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA. wjsulliv@iupui.edu

Country: England

AGENCY: United States NIGMS

GRANT: GM065051

ACRONYM: GM

MEDLINETA: Cell Microbiol

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