Histone H1 kinase specific to the SPKK motif.

Histone H1 kinase specific to the SPKK motif. Research Abstract Details 

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Histone H1 kinase specific to the SPKK motif. Abstract Text:

M Suzuki,H Sohma,M Yazawa,K Yagi,S Ebashi,

A protein kinase phosphorylating sea urchin spermatogenous histones, H1 and H2B, was found in sea urchin egg homogenate and purified. The kinase is activated by cAMP and is composed of two different types of subunits with molecular masses 41 and 46 kDa. The kinase phosphorylates a peptide, Ser-Pro-Arg-Lys-Ser-Pro-Arg-Lys, which is a double repeat of the DNA-binding SPKK motif [Suzuki M., (1989) EMBO J. 8, 797-804]. We name this kinase SPkinase because it exclusively phosphorylates H1 and H2B, the only histones containing SPKK motifs. Phosphorylation of H1 by SPkinase decreases the DNA-binding ability of H1. This paper is the first to report purification of a kinase which affects the DNA-binding ability of a gene regulatory protein.

Histone H1 kinase specific to the SPKK motif. Publishing Authors By Initials

M Suzuki,H Sohma,M Yazawa,K Yagi,S Ebashi,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research

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Histone H1 kinase specific to the SPKK motif. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 108

Page Numbers: 356-64

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1990

Histone H1 kinase specific to the SPKK motif. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Histone H1 kinase specific to the SPKK motif. Keywords Mesh Terms:

KEYWORDS: Substrate Specificity

MESH TERMS: enzymology

Chemical & Substance for Abstract: Histone H1 kinase specific to the SPKK motif. Information

Substance Name: Maturation-Promoting Factor

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Histone H1 kinase specific to the SPKK motif.

AFFILIATION: National Institute for Physiological Sciences, Aichi.

Country: JAPAN

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MEDLINETA: J Biochem

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