Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells.

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Abstract Text:

Shujuan Jiang,Sean C Dowdy,Xue W Meng,Zhaoyu Wang,Monica B Jones,Karl C Podratz,Shi-Wen Jiang,

OBJECTIVE: To characterize the molecular pathways involved in apoptosis following administration of histone deacetylase inhibitors to Type I and II endometrial cancer cells. METHODS: Ark2, Ishikawa, and AN3 cell lines representing both Type I and II endometrial cancers were treated with various concentrations of oxamflatin and HDAC inhibitor-1. Cell apoptosis was determined by flow cytometry, nuclear staining, Western blotting, and mitochondrial membrane potential assays. RESULTS: Compared to controls, there was a 95% reduction in the growth of Ark2 cells following administration of histone deacetylase inhibitors and this response was dose-dependent. These agents also caused profound morphologic changes and loss of mitochondrial membrane potentials consistent with the induction of apoptosis. Cleavage of PARP, caspase-9, and caspase-8 was detected, confirming the activation of apoptotic cascades in endometrial carcinoma cells. This effect was present in both serous and endometrioid cell types. CONCLUSION: Our results suggest that oxamflatin and HDAC inhibitor-1 have potent cytotoxicity in endometrial cancer cells by inducing cell apoptosis. Histone deacetylase inhibitors are promising agents for the treatment of both Type I and II endometrial carcinoma.

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Publishing Authors By Initials

S Jiang,SC Dowdy,XW Meng,Z Wang,MB Jones,KC Podratz,SW Jiang,

For similar organic chemicals: amines: hydroxylamines: hydroxamic acids research abstracts see: organic chemicals: amines: hydroxylamines: hydroxamic acids research

PUBMED ID PMID:

MEDLINE DATE:

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gynecologic oncology

VOLUME: 105

Page Numbers: 493-500

Journal Abbreviation:

ISSN: 0090-8258

DAY: 15

MONTH: 02

YEAR: 2007

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 365304

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Keywords Mesh Terms:

KEYWORDS: Hydroxamic Acids

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells. Information

Substance Name: Histone Deacetylases

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells.

AFFILIATION: Shandong Provincial Hospital, Jinan, P.R. China.

Country: United States

AGENCY: United States NICHD

GRANT: R01 HD41577

ACRONYM: HD

MEDLINETA: Gynecol Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells Related Publications

• Mesh-based enhancement schemes in diffuse optical tomography.
• Studies on middle silkgland proteins of cocoon colour sex-limited silkworm (Bombyx mori L.) using two-dimensional polyacrylamide gel electrophoresis.
• [5-Aminolevulinic acid esters based photodynamic therapy]
• [Administration of motilin into the lateral hypothalamus increases gastric antrum motility and activates the dorsal vagal complex in rats]
• [Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes]
• [An experimental study of cultured keratinocytes on the acellular xenodermis]
• [An experimental study on the apoptosis of rabbit small intestinal cells during early postburn stage]
• [An investigation of polymorphism in IL-1R1 gene in Chinese population and the functional prediction of a variation in the transmembrane region of IL-1R1]
• [Analysis of clinical application for various types of esophageal stents made in China]
• [Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene]
• [Cardiac presentations in patients with SARS]
• [Construction of expression vector with antisense Rubisco activase gene and its genetic transformation in rice]
• [Development of a software for realtime display of physiological informations in human centrifuge training equipment]
• [Effect of general and epidural anesthesia on autonomic nervous system]
• [Effects of different catechins on cell cycle arrest and induction of apoptosis in LoVo cells]
• [Evaluation of clinical value of anorectal manometry for diagnosis of Hirschsprung's disease in neonate]
• [Gene expression profile in early differentiation of K562 cells induced by matrine]
• [Human-centered ergonomical study and applications in manned spacecraft project of China]
• [Lung autotransplantation technique in the treatment of stage III bronchogenic carcinoma]
• [Operated diabetes insipidus treated by supplementing Qi and activating blood circulation and warming Yang to reinforce]
• [Periodic changes in serum testosterone levels after ejaculation in men]
• [Prognosis evaluation and statistical analysis]
• [Studies on transference of hydrogenase genes of Rhizobium arachis]
• [Study on single nucleotide polymorphism of TLR4 in Chinese population]
• [Study on the changes in endogenous oxidation agents and levels of anti-oxidation agents in patients with cerebral vascular disease]
• [Synthesis and characteristics of porous hydroxyapatite bioceramics]
• [The answers of questions in application of critical ill scoring systems]
• [The difference of intracellular cytokines produced by different lymphocyte subsets of cord blood and adult peripheral blood]
• [The study of countermeasures on measles control in infants]
• [Unrelated peripheral blood stem cell transplantation for a patient with acute myeloid leukemia]