Histology and immunohistology of bone marrow biopsy in multiple myeloma.

Histology and immunohistology of bone marrow biopsy in multiple myeloma. Research Abstract Details 

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Histology and immunohistology of bone marrow biopsy in multiple myeloma. Abstract Text:

B5-fixed/paraffin-embedded Jamshidi needle biopsies from 125 multiple myeloma patients were reviewed according to both morphological and immunohistological criteria. At microscopic examination, the following parameters were evaluated: i) grade of malignancy (low = 56; intermediate = 50; high = 19); ii) growth pattern (interstitial +/- sheets/nodules = 90; nodular = 13; packed marrow = 18; sarcomatous = 4); III) histological stage (I = 64; II = 35; III = 26). Comparison of the findings in trephine biopsies and aspirates showed that in 30% of the cases the latter led to an underestimation of the tumor burden. Immunohistochemical determination of Ig easily allowed: i) differential diagnosis from exuberant reactive plasmacytosis; ii) recognition and counting of neoplastic plasma cells; iii) detection of minimal residual disease after treatment. Immunohistochemistry also confirmed phenotypic aberration of neoplastic plasma cells, showing positivity for CD45, EMA, and cytokeratins in 14%, 59%, and 25% of the cases, respectively. Furthermore, it displayed expression of the P-glycoprotein in 4/8 resistant cases. These findings underline that routinely processed Jamshidi needle biopsies can be of great value in the study of patients with multiple myeloma.

Histology and immunohistology of bone marrow biopsy in multiple myeloma. Publishing Authors By Initials

For similar neoplasms: neoplasms, multiple primary research abstracts see: neoplasms: neoplasms, multiple primary research

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Histology and immunohistology of bone marrow biopsy in multiple myeloma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of haematology. Supplementum

VOLUME: 51

Page Numbers: 52-9

Journal Abbreviation:

ISSN: 0902-4506

DAY: 26

MONTH: 02

YEAR: 1989

Histology and immunohistology of bone marrow biopsy in multiple myeloma. Information

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LANGUAGE: eng

NlmUniqueID: 8703474

Histology and immunohistology of bone marrow biopsy in multiple myeloma. Keywords Mesh Terms:

KEYWORDS: Neoplasms, Multiple Primary

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Histology and immunohistology of bone marrow biopsy in multiple myeloma. Information

Substance Name: Neoplasm Proteins

Registry Number: 0

Grant and Affiliation Information for Histology and immunohistology of bone marrow biopsy in multiple myeloma.

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Country: DENMARK

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MEDLINETA: Eur J Haematol Suppl

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