Histological subclassification of cirrhosis based on histological-haemodynamic correlation.

Histological subclassification of cirrhosis based on histological-haemodynamic correlation. Research Abstract Details 

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Histological subclassification of cirrhosis based on histological-haemodynamic correlation. Abstract Text:

M Kumar,P Sakhuja,A Kumar,N Manglik,A Choudhury,S Hissar,A Rastogi,S K Sarin,M Kumar,P Sakhuja,A Kumar,N Manglik,A Choudhury,S Hissar,A Rastogi,S K Sarin,

BACKGROUND: Determining a relationship between specific histological parameters in cirrhosis and hepatic venous pressure gradient can be used to subclassify cirrhosis. AIM: To determine the relationship between hepatic venous pressure gradient and specific histological parameters in cirrhosis. METHODS: Forty-seven patients (mean age: 46.2 +/- 13.6 years; 36 male) with biopsy-proven cirrhosis and hepatic venous pressure gradient measurements within 1 month of biopsy were studied. The following histological parameters were scored semiquantitatively: nodule size, loss of portal tracts and central veins, portal inflammation, periportal inflammation, bile duct proliferation, lobular inflammation, ballooning, fatty change, cholestasis and septal thickness. RESULTS: On multiple ordinal regression analysis, small nodule size (odds ratio: 21.0; 95% confidence interval: 2.1-208.2, P = 0.009) and thick septa (OR: 42.6; CI: 2.3-783.7, P = 0.011) were significantly associated with the presence of clinically significant portal hypertension. A score was assigned to each of the two parameters (nodule size: large = 1, medium = 2, small = 3 and septal thickness: thin = 1, medium = 2, thick = 3). Two subcategories were devised based on the composite score: category A (n = 12): score 1-3 and category B (n = 35): score 4-6. On ordinal regression, subcategory B (OR: 15.5; CI: 3.3-74.2, P = 0.001) was significantly associated with clinically significant portal hypertension. CONCLUSION: Small nodularity and thick septa are independent predictors of the presence of clinically significant portal hypertension.

Histological subclassification of cirrhosis based on histological-haemodynamic correlation. Publishing Authors By Initials

M Kumar,P Sakhuja,A Kumar,N Manglik,A Choudhury,S Hissar,A Rastogi,SK Sarin,M Kumar,P Sakhuja,A Kumar,N Manglik,A Choudhury,S Hissar,A Rastogi,SK Sarin,

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Histological subclassification of cirrhosis based on histological-haemodynamic correlation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Alimentary pharmacology & therapeutics

VOLUME: 27

Page Numbers: 771-9

Journal Abbreviation: Aliment. Pharmacol. Ther.

ISSN: 1365-2036

DAY: 18

MONTH: 02

YEAR: 2008

Histological subclassification of cirrhosis based on histological-haemodynamic correlation. Information

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LANGUAGE: eng

NlmUniqueID: 8707234

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AFFILIATION: Department of Gastroenterology, G.B. Pant Hospital, New Delhi, India.

Country: England

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MEDLINETA: Aliment Pharmacol Ther

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