Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer.

Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Research Abstract Details 

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Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Abstract Text:

Akiko Shiotani,Ken Haruma,Noriya Uedo,Hiroyasu Iishi,Ryu Ishihara,Masaharu Tatsuta,Mitutaka Kumamoto,Yukinori Nakae,Shingo Ishiguro,David Y Graham,

There are limited data regarding the prognostic value of the pattern of mucin expression in IM. To examine the role of the type of IM and pattern of mucin expression in IM as histological risk markers of gastric cancer, 80 patients with a history of endoscopic mucosal resection (EMR) for early gastric cancer and 80 sex and age-matched controls were studied. Serum levels of pepsinogen (PG) were measured by RIA, and MUC2, MUC5AC and MUC6 were evaluated immunohistochemically. There is a significant association between types of IM and atrophic scores or PG levels. The most incomplete IM (type II and III) preserving gastric mucin is the gastric and intestinal mixed (GI) type, whereas the complete type is the intestinal (I) type especially in the corpus lesser curve. Gastric cancer was most significantly associated with incomplete IM in the corpus lesser curve (OR=6.4; 95% CI, 2.0-21, p=0.002). Asynchronous multiple lesions were associated with incomplete IM in the corpus greater curve (OR=4.8; 95% CI, 1.4-16, p=0.01). Classification of IM obtained using fixed-point biopsy samples may enhance the ability of surveillance programs to detect patients at increased risk of gastric cancer.

Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Publishing Authors By Initials

A Shiotani,K Haruma,N Uedo,H Iishi,R Ishihara,M Tatsuta,M Kumamoto,Y Nakae,S Ishiguro,DY Graham,

For similar neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research abstracts see: neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research

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Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv : an international journal of path

VOLUME: 449

Page Numbers: 652-9

Journal Abbreviation: Virchows Arch.

ISSN: 0945-6317

DAY: 13

MONTH: 10

YEAR: 2006

Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9423843

Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Keywords Mesh Terms:

KEYWORDS: Stomach Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer. Information

Substance Name: mucin 6

Registry Number: 0

Grant and Affiliation Information for Histological risk markers for non-cardia early gastric cancer. Pattern of mucin expression and gastric cancer.

AFFILIATION: Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan. shiotani@med.kawasaki-m.ac.jp

Country: Germany

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MEDLINETA: Virchows Arch

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