Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors.

Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Research Abstract Details 

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Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Abstract Text:

K Suzuki,I Tsuge,Y Ito,H Kunii,S Baba,

To investigate the histological effect of intranodal injection of the streptococcal preparation OK-432, we performed intranodal injection in 4 patients with cervical lymph node (CLN) metastases of malignant head and neck tumors (squamous cell carcinoma (SCC) of the oropharynx, SCC of the parotid gland, malignant lymphoma, and rhabdomyosarcoma of the nasal cavity). An initial dose of 5 klinische Einheit (KE) and a maintenance dose of 10 KE of OK-432 were administered into each metastatic or residually involved CLN twice a week. The total dose of OK-432 ranged from 105 KE to 395 KE and the number of administrations ranged from 11 to 40. Post treatment histological examination of excised tissue specimens revealed no tumor cells; there was only fibrosis and inflammatory cell infiltration. These findings suggest that intranodal injection of OK-432 can be utilized for treatment of relatively small CLN metastases of malignant head and neck tumors.

Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Publishing Authors By Initials

K Suzuki,I Tsuge,Y Ito,H Kunii,S Baba,

For similar neoplasms: neoplasms by histologic type: neoplasms, connective and soft tissue: neoplasms, muscle tissue: myosarcoma: rhabdomyosarcoma research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, connective and soft tissue: neoplasms, muscle tissue: myosarcoma: rhabdomyosarcoma research

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Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 525

Page Numbers: 125-8

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1996

Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Keywords Mesh Terms:

KEYWORDS: Rhabdomyosarcoma

MESH TERMS: pathology

Chemical & Substance for Abstract: Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors. Information

Substance Name: Picibanil

Registry Number: 39325-01-4

Grant and Affiliation Information for Histological effect of intranodal injection of the streptococcal preparation OK-432 for cervical lymph node metastases of malignant head and neck tumors.

AFFILIATION: Department of Otolaryngology, Nagoya City University Medical School, Japan.

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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