Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model.

Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Research Abstract Details 

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Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Abstract Text:

Naomi Kobayashi,Kevin Ong,Marta Villarraga,Jeffrey Schwardt,Robert Wenz,Daisuke Togawa,Takaaki Fujishiro,A Simon Turner,Howard B Seim,Thomas W Bauer,

We investigated the histological and compressive properties of three different calcium phosphate cements (CPCs) using a sheep vertebral bone void model. One of the CPCs contained barium sulfate to enhance its radiopacity. Bone voids were surgically created in the lumbar region of 23 ovine spines - L3, L4, and L5 (n = 69 total vertebral bodies) - and the voids were filled with one of the three CPCs. A fourth group consisted of whole intact vertebrae. Histologic evaluation was performed for 30 of the 69 vertebrae 2 or 4 months after surgery along with radiographic evaluation. Compressive testing was performed on 39 vertebrae 4 months after surgery along with micro-CT analysis. All three CPCs were biocompatible and extremely osteoconductive. Osteoclasts associated with adjacent bone formation suggest that each cement can undergo slow resorption and replacement by bone and bone marrow. Compressive testing did not reveal a significant difference in the ultimate strength, ultimate strain, and structural modulus, among the three CPCs and intact whole vertebrae. Micro-CT analysis revealed good osseointegration between all three CPCs and adjacent bone. The barium sulfate did not affect the CPCs biocompatibility or mechanical properties. These results suggest that CPC might be a good alternative to polymethylmethacrylate for selected indications.

Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Publishing Authors By Initials

N Kobayashi,K Ong,M Villarraga,J Schwardt,R Wenz,D Togawa,T Fujishiro,AS Turner,HB Seim,TW Bauer,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research. Part A

VOLUME: 81

Page Numbers: 838-46

Journal Abbreviation:

ISSN: 1549-3296

DAY: 15

MONTH: Jun

YEAR: 2007

Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: radiography

Chemical & Substance for Abstract: Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model. Information

Substance Name: calcium phosphate

Registry Number: 10103-46-5

Grant and Affiliation Information for Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model.

AFFILIATION: Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR 050953

ACRONYM: AR

MEDLINETA: J Biomed Mater Res A

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