Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits.

Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits. Research Abstract Details 

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Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits. Abstract Text:

PurposeTo evaluate histologic signs of toxicity of the protein tyrosine kinase inhibitor, imatinib mesylate, in rabbit eyes.MethodsTwenty Dutch-belted rabbits underwent intravitreal injections of 0.1 ml solutions of imatinib mesylate. Ten rabbits were killed and enucleated 1 week after injection of imatinib mesylate (1.65 mg (four eyes), 165 mug (four eyes), and 16.5 mug (two eyes)). Ten rabbits injected with imatinib mesylate (165 mug (five eyes) and 825 mug (five eyes)) were enucleated 1 month later. Eyes were fixed in 10% formalin and stained with haematoxylin and eosin for microscopic examination.ResultsAll four eyes injected with 1.65 mg of imatinib mesylate and enucleated at 1 week demonstrated ocular toxicity. All four eyes injected with 165 mug and enucleated at 1 week showed no ocular toxicity. One of the two eyes injected with 16.5 mug and enucleated at 1 week revealed focal areas of subretinal fluid and retinal undulations, suggestive of retinal oedema. None of the 10 eyes injected with imatinib mesylate at either the 165 or 825 mug dose and enucleated at 1 month showed ocular toxicity.ConclusionsImatinib mesylate at 1.65 mg caused extensive retinal toxicity in rabbit eyes. In contrast, lower doses did not appear to cause toxicity, but may be associated with retinal oedema.Eye (2008) 22, 712-714; doi:10.1038/sj.eye.6703092; published online 1 February 2008.

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Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Eye (London, England)

VOLUME: 22

Page Numbers: 712-4

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ISSN: 0950-222X

DAY: 1

MONTH: 02

YEAR: 2008

Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 8703986

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AFFILIATION: 1Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Country: England

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MEDLINETA: Eye

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