Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity.

Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Research Abstract Details 

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Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Abstract Text:

N Kubo,Y Hori,K Tomoda,T Yamashita,T Kumazawa,

Quantitative evaluations of histamine and histamine H1 receptor were carried out in nasal mucosa of toluene diisocyanate (TDI) sensitized guinea-pigs at specific points in time during a pre-determined sensitization period. Histamine content is significantly increased at 1 week and definitely elevated after 2 weeks of sensitization. This increase was maintained throughout the sensitization period. It decreased to normal by four weeks post-sensitization. Also the relatively low histamine content immediately after TDI challenge indicated that a certain amount of histamine was released by TDI challenge. On the other hand, the density and affinity of the histamine H1 receptor was not found to be altered during TDI sensitization. These results suggest that enhanced histamine has a role in the development of nasal allergy, whereas the relevance of quantitative-alteration of the H1 receptor to histamine hypersensitivity observed in nasal allergy has not been demonstrated.

Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Publishing Authors By Initials

N Kubo,Y Hori,K Tomoda,T Yamashita,T Kumazawa,

For similar organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: benzene derivatives: toluene: toluene 2,4-diisocyanate research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: benzene derivatives: toluene: toluene 2,4-diisocyanate research

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Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 463

Page Numbers: 21-8

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1989

Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370355

Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Keywords Mesh Terms:

KEYWORDS: Toluene 2,4-Diisocyanate

MESH TERMS: metabolism

Chemical & Substance for Abstract: Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Information

Substance Name: Toluene 2,4-Diisocyanate

Registry Number: 584-84-9

Grant and Affiliation Information for Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity.

AFFILIATION: Department of Otolaryngology, Kansai Medical University, Osaka, Japan.

Country: SWEDEN

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MEDLINETA: Acta Otolaryngol Suppl

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