Hippocampus-specific fMRI group activation analysis using the continuous medial representation.

Hippocampus-specific fMRI group activation analysis using the continuous medial representation. Research Abstract Details 

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Hippocampus-specific fMRI group activation analysis using the continuous medial representation. Abstract Text:

Paul A Yushkevich,John A Detre,Dawn Mechanic-Hamilton, ,Kathy Z Tang,Angela Hoang,Marc Korczykowski,Hui Zhang,James C Gee,

We present a new shape-based approach for regional group activation analysis in fMRI studies. The method restricts anatomical normalization, spatial smoothing and random effects statistical analysis to the space inside and around a structure of interest. Normalization involves finding intersubject correspondences between manually outlined masks, and it leverages the continuous medial representation, which makes it possible to extend surface-based shape correspondences to the space inside and outside of structures. Our approach is an alternative to whole-brain normalization in cases where the latter may fail due to anatomical variability or pathology. It also provides an opportunity to analyze the shape and thickness of structures concurrently with functional activation. We apply the technique to the hippocampus and evaluate it using data from a visual scene encoding fMRI study, where activation in the hippocampus is expected. We produce detailed statistical maps of hippocampal activation, as well as maps comparing activation inside and outside of the hippocampus. We find that random effects statistics computed by the new approach are more significant than those produced using the Statistical Parametric Mapping framework (Friston, K.J., Holmes, A.P., Worsley, K.J., Poline, J.-P., Firth, C.D., Frackowiak, R.S.J. 1994, Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping, 2(4): 189-210) at low levels of smoothing, suggesting that greater specificity can be achieved by the new method without a severe tradeoff in sensitivity.

Hippocampus-specific fMRI group activation analysis using the continuous medial representation. Publishing Authors By Initials

PA Yushkevich,JA Detre,D Mechanic-Hamilton,MA ,KZ Tang,A Hoang,M Korczykowski,H Zhang,JC Gee,

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Hippocampus-specific fMRI group activation analysis using the continuous medial representation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NeuroImage

VOLUME: 35

Page Numbers: 1516-30

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ISSN: 1053-8119

DAY: 22

MONTH: 02

YEAR: 2007

Hippocampus-specific fMRI group activation analysis using the continuous medial representation. Information

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LANGUAGE: eng

NlmUniqueID: 9215515

Hippocampus-specific fMRI group activation analysis using the continuous medial representation. Keywords Mesh Terms:

KEYWORDS: Models, Neurological

MESH TERMS: physiology

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Grant and Affiliation Information for Hippocampus-specific fMRI group activation analysis using the continuous medial representation.

AFFILIATION: Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, 3600 Market St., Ste 370, Philadelphia, PA 19104, USA. pauly2@grasp.upenn.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS045839

ACRONYM: NS

MEDLINETA: Neuroimage

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