Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury.

Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Research Abstract Details 

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Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Abstract Text:

Elisabeth A Wilde,Erin D Bigler,Jill V Hunter,Michael A Fearing,Randall S Scheibel,Mary R Newsome,Jamie L Johnson,Jocelyne Bachevalier,Xiaoqi Li,Harvey S Levin,

While closed head injury frequently results in damage to the frontal and temporal lobes, damage to deep cortical structures, such as the hippocampus, amygdala, and basal ganglia, has also been reported. Five deep central structures (hippocampus, amygdala, globus pallidus, putamen, and caudate) were examined in 16 children (eight males, eight females; aged 9-16y), imaged 1 to 10 years after moderate-to-severe traumatic brain injury (TBI), and in 16 individually-matched uninjured children. Analysis revealed significant volume loss in the hippocampus, amydala, and globus pallidus of the TBI group. Investigation of relative volume loss between these structures and against five cortical areas (ventromedial frontal, superomedial frontal, lateral frontal, temporal, and parieto-occipital) revealed the hippocampus to be the most vulnerable structure following TBI (i.e. greatest relative difference between the groups). In a separate analysis excluding children with focal hippocampal abnormalities (e.g. lesions), group differences in hippocampal volume were still evident, suggesting that hippocampal damage may be diffuse rather than focal.

Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Publishing Authors By Initials

EA Wilde,ED Bigler,JV Hunter,MA Fearing,RS Scheibel,MR Newsome,JL Johnson,J Bachevalier,X Li,HS Levin,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: temporal lobe research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: temporal lobe research

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Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental medicine and child neurology

VOLUME: 49

Page Numbers: 294-9

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ISSN: 0012-1622

DAY: 3

MONTH: Apr

YEAR: 2007

Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Information

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LANGUAGE: eng

NlmUniqueID: 6761

Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Keywords Mesh Terms:

KEYWORDS: Temporal Lobe

MESH TERMS: pathology

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Grant and Affiliation Information for Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury.

AFFILIATION: Baylor College of Medicine, Houston, TX 77030, USA. ewilde@bcm.tmc.edu

Country: England

AGENCY: United States NICHD

GRANT: U19 HD-35476

ACRONYM: HD

MEDLINETA: Dev Med Child Neurol

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