Hippocampal shape deformity analysis in obsessive-compulsive disorder.

Hippocampal shape deformity analysis in obsessive-compulsive disorder. Research Abstract Details 

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Hippocampal shape deformity analysis in obsessive-compulsive disorder. Abstract Text:

Soon Beom Hong,Yong-Wook Shin,Sun Hyung Kim,So Young Yoo,Jong-Min Lee,In Young Kim,Sun I Kim,Jun Soo Kwon,

Abnormalities of orbital prefrontal cortex and caudate nuclei have, thus far, been the main findings regarding the pathophysiology of obsessive-compulsive disorder (OCD). On the other hand, neuroimaging studies have failed to reach a consensus with regard to the issue of hippocampal abnormalities in OCD patients. Shape analysis may facilitate a resolution of the discordance among these former studies by detecting local structural changes, thus enhancing power to discriminate structural differences. It has been suggested that neural circuitry interconnecting brain areas may critically influence the shape of neuroanatomical structures, serving as a rationale for better sensitivity of shape analysis compared to volume analysis, especially in detecting abnormalities of neural circuitry. Shape analysis of the hippocampus was performed in 22 matched pairs of OCD patients and normal control subjects. As a result, we observed a bilateral hippocampal shape deformity including the most prominent characteristic of downward displacement of the head. The hippocampal structural alteration observed in this study indicates that this structure may play a role in the pathophysiology of OCD. Also, further considering the hippocampal neural connections specific to its surface topography, these surface deformities may reflect developmental alterations in these patients with regard to the neural circuitry involving hippocampus.

Hippocampal shape deformity analysis in obsessive-compulsive disorder. Publishing Authors By Initials

SB Hong,YW Shin,SH Kim,SY Yoo,JM Lee,IY Kim,SI Kim,JS Kwon,

For similar mental disorders: anxiety disorders: obsessive-compulsive disorder research abstracts see: mental disorders: anxiety disorders: obsessive-compulsive disorder research

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Hippocampal shape deformity analysis in obsessive-compulsive disorder. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European archives of psychiatry and clinical neuro

VOLUME: 257

Page Numbers: 185-90

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ISSN: 0940-1334

DAY: 26

MONTH: 04

YEAR: 2007

Hippocampal shape deformity analysis in obsessive-compulsive disorder. Information

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LANGUAGE: eng

NlmUniqueID: 9103030

Hippocampal shape deformity analysis in obsessive-compulsive disorder. Keywords Mesh Terms:

KEYWORDS: Obsessive-Compulsive Disorder

MESH TERMS: pathology

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Grant and Affiliation Information for Hippocampal shape deformity analysis in obsessive-compulsive disorder.

AFFILIATION: Department of Psychiatry, Seoul National University College of Medicine, SNUMRC, 28 Yongon-dong, Chongno-gu, 110-744 Seoul, Korea. kwonjs@plaza.snu.ac.kr

Country: Germany

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MEDLINETA: Eur Arch Psychiatry Clin Neuro

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