Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments.

Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments. Research Abstract Details 

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Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments. Abstract Text:

Monica K Chawla,Carol A Barnes,Monica K Chawla,Carol A Barnes,

Normal aging, in the absence of neurodegenerative disease, can provide important insights into the mechanisms by which the brain can maintain cognitive abilities across the lifespan. Hippocampal-dependent memory processes can become vulnerable as age advances. The focus of this chapter is the contribution of hippocampal granule cells to cognitive impairments that are observed during aging. A number of alterations in structure, function, and gene expression have been observed in aged granule cells, any of which may lead to adaptive, compensatory or detrimental consequences to hippocampal function. As the average life span of humans continues to increase, those who reach 100 years or beyond is more common. Individuals that have aged successfully, and exhibit high levels of cognitive ability can provide useful clues into the enormous potential possessed by the mammalian brain.

Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments. Publishing Authors By Initials

MK Chawla,CA Barnes,MK Chawla,CA Barnes,

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Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Progress in brain research

VOLUME: 163

Page Numbers: 661-821

Journal Abbreviation: Prog. Brain Res.

ISSN: 0079-6123

DAY: 3

MONTH: 09

YEAR: 2007

Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments.

AFFILIATION: Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Life Sciences North, Room 384, P.O. Box 245115, Tucson, AZ 85724, USA; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ 85724, USA.

Country: Netherlands

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MEDLINETA: Prog Brain Res

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