Highly effective in vivo gene transfection by blocked star vector.

Highly effective in vivo gene transfection by blocked star vector. Research Abstract Details 

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Highly effective in vivo gene transfection by blocked star vector. Abstract Text:

Y Zhou,H Huang,Y Nakayama,

Nano-structured four branched, blocked star vector (BSV) was molecular designed by iniferter-based photo-living radical copolymerization method of N,N-dimethylaminopropylacrylamide and then N,N-dimethylacrylamide from four dithiocarbamate-derivatized benzene for a novel gene derivery non-viral vector. The conjugated pDNA complexes were satisfactorily stable in the condition of the electrophoresis. Under the charge ratio of 5/1 (vector/pDNA), complexes of BSV and pDNA (BSV-pDNA) demonstrated satisfied transfection efficiency into COS-1 cells with a little cytotoxicity. Mice injected with BSV-pDNA polyplexes showed a higher level of gene expression in either liver, kidney or spleen using the optimal charge ratio as determined in in vitro. These results suggest the potential use of BSV as a non-viral vector in clinic.

Highly effective in vivo gene transfection by blocked star vector. Publishing Authors By Initials

Y Zhou,H Huang,Y Nakayama,

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Highly effective in vivo gene transfection by blocked star vector. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 501-3

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ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

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LANGUAGE: eng

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Grant and Affiliation Information for Highly effective in vivo gene transfection by blocked star vector.

AFFILIATION: Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.

Country: United States

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MEDLINETA: Conf Proc IEEE Eng Med Biol So

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