Highly concentrated catalytic asymmetric allylation of ketones.

Highly concentrated catalytic asymmetric allylation of ketones. Research Abstract Details 

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Highly concentrated catalytic asymmetric allylation of ketones. Abstract Text:

Alfred J Wooten,Jeung Gon Kim,Patrick J Walsh,

[reaction: see text] We report the catalytic asymmetric allylation of ketones under highly concentrated reaction conditions with a catalyst generated from titanium tetraisopropoxide and BINOL (1:2 ratio) in the presence of isopropanol. This catalyst promotes the addition of tetraallylstannane to a variety of ketones to produce tertiary homoallylic alcohols in excellent yield (80-99%) with high enantioselectivities (79-95%). The resulting homoallylic alcohols can also be epoxidized in situ using tert-butyl hydroperoxide (TBHP) to afford cyclic epoxy alcohols in high yield (84-87%).

Highly concentrated catalytic asymmetric allylation of ketones. Publishing Authors By Initials

AJ Wooten,JG Kim,PJ Walsh,

For similar tert-butylhydroperoxide research abstracts see: tert-butylhydroperoxide research

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Highly concentrated catalytic asymmetric allylation of ketones. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic letters

VOLUME: 9

Page Numbers: 381-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 1

MONTH: Feb

YEAR: 2007

Highly concentrated catalytic asymmetric allylation of ketones. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

Highly concentrated catalytic asymmetric allylation of ketones. Keywords Mesh Terms:

KEYWORDS: tert-Butylhydroperoxide

MESH TERMS: chemistry

Chemical & Substance for Abstract: Highly concentrated catalytic asymmetric allylation of ketones. Information

Substance Name: tert-Butylhydroperoxide

Registry Number: 75-91-2

Grant and Affiliation Information for Highly concentrated catalytic asymmetric allylation of ketones.

AFFILIATION: P. Roy and Diana T. Vagelos Laboratories, University of Pennsylvania, Department of Chemistry, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM58101

ACRONYM: GM

MEDLINETA: Org Lett

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