Highly active antiretroviral therapy and survival in HIV-infected injection drug users.

Highly active antiretroviral therapy and survival in HIV-infected injection drug users. Research Abstract Details 

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Highly active antiretroviral therapy and survival in HIV-infected injection drug users. Abstract Text:

CONTEXT: Highly active antiretroviral therapy (HAART) is often withheld from injection drug users (IDUs) infected with the human immunodeficiency virus (HIV) based on the belief that their unstable lifestyles may predetermine a markedly inferior outcome with HAART. However, long-term evaluations of HIV treatment outcomes among IDUs in comparison with other risk groups are not available. OBJECTIVE: To compare survival rates among HIV-infected patients initiating HAART with and without a history of injection drug use. DESIGN, SETTING, AND PATIENTS: Population-based, prospective cohort study (HAART Observational Medical Evaluation and Research [HOMER]) of 3116 antiretroviral-naive HIV-infected patients in a province-wide HIV/AIDS treatment program in British Columbia, Canada. Of the 3116 patients, 915 were IDUs (29.4%), 579 were female (18.6%), and the median age was 39.4 years (interquartile range, 33.3-46.4 years). Treatment with HAART was initiated between August 1, 1996, and June 30, 2006. The median duration of follow-up was 5.3 years (interquartile range, 2.8-8.3 years) for IDUs and 4.3 years (interquartile range, 2.0-7.6 years) for non-IDUs. Patients were followed up until June 30, 2007. Data were analyzed between November 1, 2007, and May 26, 2008. MAIN OUTCOME MEASURE: All-cause mortality. RESULTS: Overall, 622 individuals died (20.0%) during the study period (232 IDUs and 390 non-IDUs), for a crude mortality rate of 20.0% (95% confidence interval [CI], 18.4%-21.5%). At 84 months after the initiation of HAART, the product limit estimate of the cumulative all-cause mortality rate was similar between the 915 IDUs (26.5%; 95% CI, 23.2%-29.8%) and 2201 non-IDUs (21.6%; 95% CI, 16.9%-26.2%) (Wilcoxon P = .47). In multivariate time-updated Cox regression, the hazard ratio of mortality was similar between IDUs and non-IDUs (1.09; 95% CI, 0.92-1.29). CONCLUSION: In this study population, injection drug use was not associated with decreased survival among HIV-infected patients initiating HAART.

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Highly active antiretroviral therapy and survival in HIV-infected injection drug users. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: JAMA : the journal of the American Medical Associa

VOLUME: 300

Page Numbers: 550-4

Journal Abbreviation: JAMA

ISSN: 1538-3598

DAY: 6

MONTH: Aug

YEAR: 2008

Highly active antiretroviral therapy and survival in HIV-infected injection drug users. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Highly active antiretroviral therapy and survival in HIV-infected injection drug users.

AFFILIATION: British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital, Vancouver, BC, Canada.

Country: United States

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MEDLINETA: JAMA

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