High serum IGFBP-2 is predictive of increased bone turnover in aging men and women.

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Research Abstract Details 

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High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Abstract Text:

Shreyasee Amin,B Lawrence Riggs,L Joseph Melton,Sara J Achenbach,Elizabeth J Atkinson,Sundeep Khosla,

Elevated serum IGFBP-2 is associated with lower BMD in men and women. It is unknown whether IGFBP-2 serves as a negative regulator of bone metabolism by decreasing bone formation or increasing bone resorption. Studying an age-stratified community-based sample of 344 men and 276 women, IGFBP-2 was the strongest predictor of increased bone resorption among the IGF/IGFBPs studied. INTRODUCTION: Serum insulin-like growth factor binding protein-2 (IGFBP-2), which increases with age, is a predictor of low BMD among aging men and women. However, it is unknown whether IGFBP-2 negatively influences bone metabolism by decreasing bone formation or increasing bone resorption. Few have examined the relation between the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) with bone turnover markers. MATERIALS AND METHODS: In an age-stratified, random sample of the community, we examined the association between serum IGF-I, IGF-II, IGFBP-1, -2, and -3, and bone turnover markers before and after adjustment for potential confounders (age, body mass index, bioavailable estradiol and testosterone, and sex hormone binding globulin). Analyses were stratified by sex and menopausal status. RESULTS: We studied 344 men (age range, 23-90 yr) and 276 women (age range, 21-93 yr; 166 postmenopausal) not on oral contraceptives or hormone replacement. Among the IGF/IGFBPs assessed, IGFBP-2 was the strongest and most consistent predictor of bone turnover in men and women. After adjustment for potential confounders, IGFBP-2 was positively associated with osteocalcin (OC) and urine and serum N-teleopeptide (NTX) in men (r = 0.20, 0.26, and 0.23, respectively; p < 0.001), serum C-telopeptide (CTX) in premenopausal women (r = 0.28; p < 0.01), and OC, urine NTX, and serum CTX in postmenopausal women (r = 0.24, 0.33, and 0.19, respectively; p < 0.05). CONCLUSIONS: Higher serum IGFBP-2, which is predictive of lower BMD, is associated with increased markers of bone resorption, independent of age, body mass, and sex hormones. The association between IGFBP-2 and markers of bone formation may reflect coupling with increased bone resorption, which is not adequate to maintain BMD.

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Publishing Authors By Initials

S Amin,BL Riggs,LJ Melton,SJ Achenbach,EJ Atkinson,S Khosla,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of bone and mineral research : the officia

VOLUME: 22

Page Numbers: 799-807

Journal Abbreviation: J. Bone Miner. Res.

ISSN: 0884-0431

DAY: 3

MONTH: Jun

YEAR: 2007

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8610640

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: blood

Chemical & Substance for Abstract: High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for High serum IGFBP-2 is predictive of increased bone turnover in aging men and women.

AFFILIATION: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. amin.shreyasee@mayo.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR00585

ACRONYM: RR

MEDLINETA: J Bone Miner Res

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