High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome.

High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Research Abstract Details 

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High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Abstract Text:

Zhigang Zhao,Hai Nie,Hongbo He,Zhencheng Yan,Daoyan Liu,Zhidan Luo,Liqun Ma,Yinxing Ni,Jin Chen,Jin Jing,Tingbing Cao,Hua Yang,Martin Tepel,Weiguo Zhang,Zhiming Zhu,Zhigang Zhao,Hai Nie,Hongbo He,Zhencheng Yan,Daoyan Liu,Zhidan Luo,Liqun Ma,Yinxing Ni,Jin Chen,Jin Jing,Tingbing Cao,Hua Yang,Martin Tepel,Weiguo Zhang,Zhiming Zhu,Zhigang Zhao,Hai Nie,Hongbo He,Zhencheng Yan,Daoyan Liu,Zhidan Luo,Liqun Ma,Yinxing Ni,Jin Chen,Jin Jing,Tingbing Cao,Hua Yang,Martin Tepel,Weiguo Zhang,Zhiming Zhu,

Observational studies established high-sensitivity C-reactive protein as a risk factor for cardiovascular events in the general population. The goal of this study was to determine the relationship between target organ damage and high-sensitivity C-reactive protein in a cohort of Chinese patients with metabolic syndrome. A total of 1082 consecutive patients of Chinese origin were screened for the presence of metabolic syndrome according to the National Cholesterol Education Program's Adult Treatment Panel III. High-sensitivity C-reactive protein and target organ damage, including cardiac hypertrophy, carotid intima-media thickness, and renal impairment, were investigated. The median (25th and 75th percentiles) of high-sensitivity C-reactive protein in 619 patients with metabolic syndrome was 2.42 mg/L (0.75 and 3.66 mg/L) compared with 1.13 mg/L (0.51 and 2.46 mg/L) among 463 control subjects (P < .01). There was a progressive increase in high-sensitivity C-reactive protein level with the number of components of the metabolic syndrome. Stratification of patients with metabolic syndrome into 3 groups according to their high-sensitivity C-reactive protein concentrations (<1.0, 1.0-3.0, and >3.0 mg/L) showed that the subjects with the elevated high-sensitivity C-reactive protein had a higher percentage of target organ damage than those with lower high-sensitivity C-reactive protein. Stepwise multiple logistic regression confirmed that high-sensitivity C-reactive protein was significantly associated with cardiac hypertrophy, carotid intima-media thickness, and renal impairment. The study shows a strong independent association between inflammation and target organ damage in a large cohort of patients of Chinese origin with metabolic syndrome.

High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Publishing Authors By Initials

Z Zhao,H Nie,H He,Z Yan,D Liu,Z Luo,L Ma,Y Ni,J Chen,J Jing,T Cao,H Yang,M Tepel,W Zhang,Z Zhu,Z Zhao,H Nie,H He,Z Yan,D Liu,Z Luo,L Ma,Y Ni,J Chen,J Jing,T Cao,H Yang,M Tepel,W Zhang,Z Zhu,Z Zhao,H Nie,H He,Z Yan,D Liu,Z Luo,L Ma,Y Ni,J Chen,J Jing,T Cao,H Yang,M Tepel,W Zhang,Z Zhu,

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High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Metabolism: clinical and experimental

VOLUME: 56

Page Numbers: 1612-9

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ISSN: 0026-0495

DAY: 13

MONTH: Dec

YEAR: 2007

High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 375267

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Grant and Affiliation Information for High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome.

AFFILIATION: Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

Country: United States

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MEDLINETA: Metabolism

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