High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation.

High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. Research Abstract Details 

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High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. Abstract Text:

Steven N Truong,Suhail Alam,Robert J Zawadzki,Stacey S Choi,David G Telander,Susanna S Park,John S Werner,Lawrence S Morse,

PURPOSE: To study the anatomic details of retinal angiomatous proliferation (RAP) in patients with age-related macular degeneration (AMD) using high-resolution Fourier-domain optical coherence tomography (Fd-OCT) and its three-dimensional reconstructions. METHODS: A Fd-OCT instrument was used to image five patients clinically diagnosed with RAP. A series of 100 raster-scanned B-scans centered over the macula was registered and rendered as a three-dimensional volume. These retinal structures were analyzed for anatomic details of the RAP lesions. RESULTS: The RAP lesion could be identified within the retina on Fd-OCT in all five cases. Fd-OCT images of the first four cases revealed areas of intraretinal neovascularization (IRN) in the deep retina adjacent to a pigment epithelial detachment (PED). There was neovascular proliferation anteriorly and posteriorly through a break in the retinal pigment epithelium (RPE). In three of the four cases, Bruch membrane remained intact. There was no identifiable choroidal neovascularization (CNV). The fifth case had both subretinal and sub-RPE neovascular membranes without a PED. CONCLUSION: Fd-OCT provides unprecedented in vivo detail of the anatomy of RAP lesions that nearly resembles histologic specimens. This study suggests that the initial neovascular process in RAP can originate either within the retina or in the sub-RPE space.

High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. Publishing Authors By Initials

SN Truong,S Alam,RJ Zawadzki,SS Choi,DG Telander,SS Park,JS Werner,LS Morse,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: tomography: tomography, optical: tomography, optical coherence research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: tomography: tomography, optical: tomography, optical coherence research

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High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Retina (Philadelphia, Pa.)

VOLUME: 27

Page Numbers: 915-25

Journal Abbreviation: Retina (Philadelphia, Pa.)

ISSN: 0275-004X

DAY: 19

MONTH: Sep

YEAR: 2007

High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. Information

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LANGUAGE: eng

NlmUniqueID: 8309919

High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation. Keywords Mesh Terms:

KEYWORDS: Tomography, Optical Coherence

MESH TERMS: methods

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Grant and Affiliation Information for High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation.

AFFILIATION: Department of Ophthalmology and Vision Science, University of California, Davis Medical Center, USA.

Country: United States

AGENCY: United States PHS

GRANT: 014743

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MEDLINETA: Retina

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