High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis.

High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Research Abstract Details 

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High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Abstract Text:

David A Zisman,Arun S Karlamangla,David J Ross,Michael P Keane,John A Belperio,Rajan Saggar,Joseph P Lynch,Abbas Ardehali,Jonathan Goldin,

BACKGROUND: Reliable, noninvasive approaches to the diagnosis of pulmonary hypertension (PH) in patients with idiopathic pulmonary fibrosis (IPF) are needed. We tested the hypothesis that chest CT-determined extent of pulmonary fibrosis and/or main pulmonary artery diameter (MPAD) can be used to identify the presence of PH in patients with advanced IPF. METHODS: Cross-sectional study of 65 patients with advanced IPF and available right-heart catheterization and high-resolution chest CT. An expert radiologist scored ground-glass opacity, lung fibrosis, and honeycombing in the CT images on a scale of 0 to 4. These scores were also summed into a total profusion score. The main pulmonary artery was measured at its widest dimension on the supine full-chest sequence. At this same level, the widest aorta diameter was measured. RESULTS: Chest CT-determined fibrosis score, ground-glass opacity score, honeycombing score, total profusion score, diameter of the main pulmonary artery, and the ratio of the pulmonary artery to aorta diameter did not differ between those with and without PH. There was no significant correlation between mean pulmonary artery pressure and any of the chest CT-determined measures. CONCLUSIONS: High-resolution chest CT-determined extent of pulmonary fibrosis and/or MPAD cannot be used to screen for PH in advanced IPF patients.

High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Publishing Authors By Initials

DA Zisman,AS Karlamangla,DJ Ross,MP Keane,JA Belperio,R Saggar,JP Lynch,A Ardehali,J Goldin,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Chest

VOLUME: 132

Page Numbers: 773-9

Journal Abbreviation: Chest

ISSN: 0012-3692

DAY: 15

MONTH: 06

YEAR: 2007

High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Information

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LANGUAGE: eng

NlmUniqueID: 231335

High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: radiography

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Grant and Affiliation Information for High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis.

AFFILIATION: Department of Medicine, David Geffen School of Medicine at UCLA, 37-131 Center for Health Sciences, Los Angeles, CA 90095, USA. dzisman@mednet.ucla.edu

Country: United States

AGENCY: United States NHLBI

GRANT: U10 HL080411-03

ACRONYM: HL

MEDLINETA: Chest

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