High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans.

High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Research Abstract Details 

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High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Abstract Text:

BACKGROUND: Orthostatic hypotension (OH) is defined as a reduction of systolic blood pressure of at least 20 mmHg, or diastolic blood pressure of at least 10 mmHg from a sitting to a standing position. It is a common physical finding among older adults and associated with significant morbidity and mortality. Use of medications that have the potential to induce OH, particularly concomitant use of several of such medications, is a major factor for the development of OH. OBJECTIVES: To describe the prevalence of symptomatic and asymptomatic OH in veterans aged 75 years and older attending a geriatric clinic, and to assess the association between OH and the number of potentially causative medications used. METHODS: Charts of all patients who attended a VA geriatric clinic (Michael E. DeBakey VA Medical Center) during the period of 1 June 2002 to 1 June 2003 were reviewed retrospectively for (i) the use of potentially causative medications, i.e. medications that were reported to cause OH in at least 1% of the general population and that were available in the VA formulary, (ii) the presence or absence of OH, and (iii) the presence or absence of symptomatic OH. Patients with primary autonomic dysfunction, Parkinson's disease, and patients who were unable to stand, or who had no assessment for both sitting and standing blood pressure for other reasons were excluded. RESULTS: A total of 505 individual patients attended the clinic during the study period, and 342 patients fit the inclusion criteria. About 189 of these patients (55%) had OH. Among patients with OH, 61 patients (33%) were symptomatic, including 52 patients who had falls. The prevalence of OH in patients receiving zero, one, two, and three or more potentially causative medications was 35, 58, 60 and 65% respectively. Receiving hydrochlorothiazide was associated with the highest prevalence of OH (65%), followed by receiving lisinopril (60%), trazodone (58%), furosemide (56%) and terazosin (54%). CONCLUSION: The prevalence of OH is very high in older veterans and significantly related to the number of concurrent causative medications used. Providers should be educated to reduce the amount of potentially causative medications in the elderly and better assess patients in which use of such medications is necessary to avoid symptomatic OH.

High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Publishing Authors By Initials

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High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 30

Page Numbers: 173-8

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Apr

YEAR: 2005

High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Keywords Mesh Terms:

KEYWORDS: Veterans

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. Information

Substance Name: Lisinopril

Registry Number: 83915-83-7

Grant and Affiliation Information for High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans.

AFFILIATION: Pharmacy Practice Department, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA. chui_io@tsu.edu

Country: England

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MEDLINETA: J Clin Pharm Ther

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