HIGH PERITONEAL CLEARANCE OF SMALL MOLECULES DID NOT PROVIDE LOW SERUM {beta}2-MICROGLOBULIN CONCENTRATIONS IN PERITONEAL DIALYSIS PATIENTS.

HIGH PERITONEAL CLEARANCE OF SMALL MOLECULES DID NOT PROVIDE LOW SERUM {beta}2-MICROGLOBULIN CONCENTRATIONS IN PERITONEAL DIALYSIS PATIENTS. Research Abstract Details 

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HIGH PERITONEAL CLEARANCE OF SMALL MOLECULES DID NOT PROVIDE LOW SERUM {beta}2-MICROGLOBULIN CONCENTRATIONS IN PERITONEAL DIALYSIS PATIENTS. Abstract Text:

Suguru Yamamoto,Akio Kasai,Hisaki Shimada,

OBJECTIVE: Although early reports demonstrated that serum beta(2)-microglobulin (s-beta(2)m) concentrations in patients on peritoneal dialysis (PD) were lower than those in patients on hemodialysis (HD), more recent studies demonstrated lower s-beta(2)m concentrations in HD patients treated mainly with high-flux synthetic membranes. We therefore compared s-beta(2)m concentrations between patients on PD and on HD, and also analyzed the relationship between s-beta(2)m concentrations and other parameters in patients on PD. Patients and METHODS: We investigated 24 patients who had been undergoing PD [11 on continuous ambulatory peritoneal dialysis, 13 on continuous cycling peritoneal dialysis] for 4.3 +/- 2.7 years, and 24 patients who had been undergoing HD with high-flux synthetic membranes for 6.1 +/- 3.2 years. Concentrations of s-beta(2)m in the PD patients were compared to concentrations in the HD patients. In patients on PD, we also analyzed the relationship between s-beta(2)m concentration and other parameters, including residual renal function, total weekly Kt/V urea, total weekly creatinine clearance (CCr), and dialysis schedules. RESULTS: We found no significant difference in s-beta(2)m concentrations between the PD and HD patients (33.6 +/- 10.4 mg/L vs 30.3 +/- 10.5 mg/L respectively). Concentrations of s-beta(2)m in PD patients rose with PD duration and were significantly inversely correlated with residual renal function (r = -0.71, p < 0.0001). Unexpectedly, concentrations of s-beta(2)m in anuric PD patients rose as peritoneal CCr increased. And most of the patients with high s-beta(2)m levels fell into the high or high-average transport categories according to a peritoneal equilibration test. CONCLUSIONS: Concentrations of s-beta(2)m in patients on PD did not differ significantly from concentrations in HD patients who were using high-flux synthetic membranes. The contribution of residual renal function to removal of beta(2)m was more important than the contribution of peritoneal clearance. High peritoneal clearance of small molecules did not result in low s-beta(2)m concentrations, especially in anuric patients with accelerated peritoneal permeability.

HIGH PERITONEAL CLEARANCE OF SMALL MOLECULES DID NOT PROVIDE LOW SERUM {beta}2-MICROGLOBULIN CONCENTRATIONS IN PERITONEAL DIALYSIS PATIENTS. Publishing Authors By Initials

S Yamamoto,A Kasai,H Shimada,

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HIGH PERITONEAL CLEARANCE OF SMALL MOLECULES DID NOT PROVIDE LOW SERUM {beta}2-MICROGLOBULIN CONCENTRATIONS IN PERITONEAL DIALYSIS PATIENTS. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Peritoneal dialysis international : journal of the

VOLUME: 23 Suppl 2

Page Numbers: S34-6

Journal Abbreviation:

ISSN: 0896-8608

DAY: 7

MONTH: 11

YEAR: 2003

HIGH PERITONEAL CLEARANCE OF SMALL MOLECULES DID NOT PROVIDE LOW SERUM {beta}2-MICROGLOBULIN CONCENTRATIONS IN PERITONEAL DIALYSIS PATIENTS. Information

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LANGUAGE: eng

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AFFILIATION: Department of Internal Medicine, Niigata Prefectural Central Hospital, Joetsu City, Niigata, Japan.

Country: Canada

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MEDLINETA: Perit Dial Int

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