High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma.

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Research Abstract Details 

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High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Abstract Text:

Norihiko Akamatsu,Yasuaki Yamada,Hiroo Hasegawa,Koki Makabe,Ryutaro Asano,Izumi Kumagai,Ken Murata,Yoshitaka Imaizumi,Kunihiro Tsukasaki,Kazuto Tsuruda,Kazuyuki Sugahara,Sunao Atogami,Katsunori Yanagihara,Shimeru Kamihira,

We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Publishing Authors By Initials

N Akamatsu,Y Yamada,H Hasegawa,K Makabe,R Asano,I Kumagai,K Murata,Y Imaizumi,K Tsukasaki,K Tsuruda,K Sugahara,S Atogami,K Yanagihara,S Kamihira,

For similar peptides: intracellular signaling peptides and proteins: apoptosis regulatory proteins: proto-oncogene proteins c-bcl-2: bcl-2-associated x protein research abstracts see: peptides: intracellular signaling peptides and proteins: apoptosis regulatory proteins: proto-oncogene proteins c-bcl-2: bcl-2-associated x protein research

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High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer letters

VOLUME: 256

Page Numbers: 196-206

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 10

MONTH: 07

YEAR: 2007

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Information

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LANGUAGE: eng

NlmUniqueID: 7600053

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Keywords Mesh Terms:

KEYWORDS: bcl-2-Associated X Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Information

Substance Name: Caspase 8

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma.

AFFILIATION: Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

Country: Ireland

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MEDLINETA: Cancer Lett

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