High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet.

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Research Abstract Details 

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High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Abstract Text:

Naveen Sharma,Isidore C Okere,Monika K Duda,Janean Johnson,Celvie L Yuan,Margaret P Chandler,Paul Ernsberger,Brian D Hoit,William C Stanley,

BACKGROUND: Chronic hypertension leads to cardiac hypertrophy, heart failure, and premature death. Little is known about the impact of dietary macronutrient composition on hypertension-induced cardiac hypertrophy and mortality. We investigated the effects of consuming either a high complex carbohydrate diet, a high simple sugar diet, or a high fat diet on cardiac hypertrophy and mortality in hypertensive Dahl salt-sensitive (DSS) rats. METHODS: Rats were assigned to four diets: complex carbohydrate (CC; 70% starch, 10% fat, 20% protein by energy), high fat (FAT; 20% carbohydrates, 60% fat, 20% protein), high fructose (FRU; 70% fructose, 10% fat, 20% protein), and "western" (WES; 35% fructose, 45% fat, 20% protein). Hypertension was initiated by adding 6% NaCl (+S) to the chow of half the animals within each diet (n = 10 to 13/group). Tail cuff blood pressure measurements were assessed after 5 and 11 weeks of treatment, and echocardiography were assessed after 12 weeks of treatment. RESULTS: All rats fed a high salt diet had similar levels of hypertension (CC+S 220 +/-2 mm Hg, FAT+S 221 +/- 3 mm Hg, FRU+S 221 +/- 1 mm Hg, WES+S 226 +/- 3 mm Hg). Echocardiography results show that the addition of salt to FRU resulted in increased regional wall thickness that was not observed in other dietary groups. All rats fed a low salt diet (CC, FAT, FRU, WES) and the FAT+S group survived 90 days. On the other hand, there was 90-day mortality in the WES+S group (18% mortality) and the CC+S group (30% mortality). In addition, FRU+S rats started dying after 45 days of salt feeding, and only 15% survived the full 90 days. CONCLUSIONS: These results demonstrate that a high fructose diet consumed during hypertension increases mortality and left ventricular (LV) wall thickness compared to either a high fat, high starch, or a "western" diet.

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Publishing Authors By Initials

N Sharma,IC Okere,MK Duda,J Johnson,CL Yuan,MP Chandler,P Ernsberger,BD Hoit,WC Stanley,

For similar cardiovascular diseases: heart diseases: ventricular dysfunction: ventricular dysfunction, left research abstracts see: cardiovascular diseases: heart diseases: ventricular dysfunction: ventricular dysfunction, left research

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High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of hypertension : journal of the

VOLUME: 20

Page Numbers: 403-9

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 3

MONTH: Apr

YEAR: 2007

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803676

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Keywords Mesh Terms:

KEYWORDS: Ventricular Dysfunction, Left

MESH TERMS: physiopathology

Chemical & Substance for Abstract: High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Information

Substance Name: Fructose

Registry Number: 30237-26-4

Grant and Affiliation Information for High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet.

AFFILIATION: Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4970, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-074237

ACRONYM: HL

MEDLINETA: Am J Hypertens

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